Proteinuria is an early marker of kidney damage that may be a manifestation of a primary renal condition, such as IgA nephropathy, or a manifestation of system disease (eg. diabetic nephropathy or systemic lupus erythematosus). A higher level of proteinuria in the setting of low kidney function, when confirmed, typically reflects an increased risk of progression to end-stage renal disease. While proteinuria can be measured in a variety of ways; the urine albumin:creatinine ratio (ACR) has become the recommended method to quantify proteinuria in most patients. The approach to proteinuria must take into account the clinical circumstances; patients with nephrotic syndrome for example should be referred urgently to nephrology. Treatment of proteinuria largely focuses on treatments to delay progression of kidney disease and/or reduce cardiovascular risk. Such treatments include blood pressure lowering, use of ace inhibitors or angiotensin receptor blockers, and glycemic control. Indications for referral to nephrology for proteinuria can be found in the Kidneywise toolkit.
Provincial Medical Lead - Early Detection and Prevention of Progression
CCO - Ontario Renal Network
A practicing academic nephrologist at St. Joseph’s Healthcare Hamilton, Dr. Scott Brimble is an Associate Professor in the Department of Medicine and is the Divisional Director of Nephrology at McMaster University. His clinical and research interests focus on CKD and ESRD care. Dr. Brimble currently works one day a week at the Ontario Renal Network as the Provincial Medical Lead for CKD Care and First Nations, Inuit and Métis Kidney Health.
Friday, November 24
10:45 AM – 11:45 AM
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