Radiation and Cancer Biology

Panel 06 - The Translational Potential of Liquid Biopsies for Predicting Radiation Response

Predicting Radiotherapy Responses and Treatment Outcomes Through Analysis of Circulating Tumor DNA

Monday, October 22
11:25 AM - 11:45 AM
Location: Room 304

Aadel Chaudhuri, MD, PhD

Washington University School of Medicine

Disclosure:
Employment
Barnes Jewish Hospital: Strategic Sourcing Manager: Employee; Washington University: Assistant Professor: Employee

Compensation
Varian Medical Systems: Honoraria

Leadership
AACR Radiation Science and Medicine Working Group: Member; NRG Oncology Radiation Therapy Developmental Therapeutics Subcommittee: Member

Biography:
Aadel Chaudhuri, MD PhD, Assistant Professor of Radiation Oncology at the Washington University Siteman Cancer Center, is a physician-scientist who recently completed his radiation oncology residency at the Stanford Cancer Institute, and postdoctoral work at Stanford University in Dr. Maximilian Diehn's lab. Under Dr. Diehn's mentorship, he led a study of localized lung cancer patients treated with definitive intent (majority with radiotherapy) and showed that circulating tumor DNA (ctDNA) was detected pre-treatment and immediately post-treatment with high sensitivity and specificity, suggesting ctDNA can be implemented as a robust biomarker for lung cancer molecular residual disease (MRD) detection and surveillance. He presented his results in the Clinical Trials session at ASTRO in San Diego in 2017, and published them in the journal Cancer Discovery. Aadel is continuing his research program studying circulating tumor DNA as a noninvasive tumor surveillance and MRD biomarker. He is also applying ctDNA and single cell sequencing to identify response biomarkers for radio-immunotherapy. His research is highly translational, and leverages his experiences as both a clinician and a scientist.

Presentation(s):

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