Breast Cancer

SS 23 - Breast 3?- General

163 - Two-Year Results of Once Daily Accelerated Partial Breast Irradiation: A Randomized Controlled Study

Tuesday, October 23
1:50 PM - 2:00 PM
Location: Room 303

Two-Year Results of Once Daily Accelerated Partial Breast Irradiation: A Randomized Controlled Study
R. Boutrus1, H. El hossieny1, S. El Sherif1, A. M. Amin1, M. Bayomy2, T. Hashim3, A. Farahat4, and M. El-Sebaie5; 1Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt, 2Clinical Oncology Department, Zagazig University., Zagazig, Egypt, 3Surgical Oncology Department, Breast Division, national Cancer Institute, Cairo University, Cairo, Egypt, 4Surgical Oncology Department, Breast Division, National Cancer Institute, Cairo University, Cairo, Egypt, 5Radiation Oncology department, National Cancer Institute, Cairo University, Cairo, Egypt

Purpose/Objective(s): To assess cosmetic and toxicity results of a randomized trial comparing once daily accelerated partial-breast irradiation (oAPBI) with twice daily accelerated partial breast irradiation (tAPBI) and whole-breast irradiation (WBI).

Materials/Methods: Women age ≥ 40 years with invasive or in situ breast cancer, ≤ 3 cm and negative lymph nodes were randomly assigned after breast-conserving surgery to either APBI 38.5 Gy in 10 once daily fractions or APBI 38.5 Gy in 10 twice daily fractions or WBI 50 Gy in 25 daily fractions ± boost. Treatments were carried out using 3D Conformal Radiation Therapy (3D-CRT). The primary outcome was ipsilateral breast tumor recurrence (IBTR). Secondary outcomes were cosmesis and toxicity. Adverse cosmesis was defined as a fair or poor cosmesis on the EORTC cosmesis rating system.

Results: Between 2014 and 2017, 91 patients were randomly assigned to 3D-CRT oAPBI (n 31), tAPBI (n 30) or WBI (n 30). Median follow-up was 20 months. No IBTRs were recorded, two patients experienced nodal recurrences, one in the oAPBI and the other in the tAPBI arm. Adverse cosmesis at 1 year was increased among those treated with tAPBI compared with oAPBI and WBI (35% vs 10% vs 16%; p 0 .039). Grade III early skin toxicities were less frequent in the oAPBI arm as compared to tAPBI and WBI (6.5%v vs. 10% vs. 33%, p 0.001). No difference was found in GIII/IV late skin toxicity (6.7% for oAPBI, 12.9% for tAPBI and 10% for WBI, p 0.79). Lower GIII late subcutaneous fibrosis was observed in the oAPBI arm (3.2%) as compared to tAPBI (10%) and WBI (6.7%), p 0.001.

Conclusion: Once daily APBI is a well tolerated regimen with better toxicity and cosmetic outcomes as compared to the twice daily APBI and WBI.

Author Disclosure: R. Boutrus: None. H. El hossieny: None. S. El Sherif: None. A.M. Amin: None.

Rimoun Boutrus, MD, PhD

Disclosure:
No relationships to disclose.

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163 - Two-Year Results of Once Daily Accelerated Partial Breast Irradiation: A Randomized Controlled Study



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