Gastrointestinal Cancer

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SU_8_2079 - PD-L1 Expression and the Effect With Radiosensitivity and Prognosis in Esophageal Squamous Cell Carcinom

Sunday, October 21
1:15 PM - 2:45 PM
Location: Innovation Hub, Exhibit Hall 3

PD-L1 Expression and the Effect With Radiosensitivity and Prognosis in Esophageal Squamous Cell Carcinom
D. Y. Ma1, X. C. Xie1, T. W. Chen2, and X. Z. Pang1; 1Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China, 2Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China

Purpose/Objective(s): The relationship between PD-L1 expression and the clinical biological behavior of esophageal squamous cell carcinoma (ESCC) has been widely debated. The purpose of the research was to investigate the relationship of PD-L1 with clinicopathological characteristics, radiotherapy response and prognosis of patients with ESCC.

Materials/Methods: The expression of PD-L1 was detected by immunohistochemical staining both on cancer and normal esophageal mucosal cells. Esophagus barium meal X-ray examination was applied to evaluation radiotherapy response lines with PD-L1 expression in ESCC. Progress-free survival (PFS) and Overall survival(OS) were analyzed by Kaplan-Meier method. differences between pairs of Kaplan-Meier curves were examined by the log-rank test. The chi-square test was used to compare correlations between pathological characteristics and PD-L1 expression. P value of 0.05 was considered statistically significant.

Results: A total of 90 patients with ESCC were included. PD-L1 staining was observed on tumor cells (56.7%), as well as normal esophageal mucosal cells (15.0%). PD-L1 protein expression was not correlated with age, gender, the maximum diameter of tumor, the length of tumor, the local aggressive of tumor, clinical stage and primary tumor volume ( P>0.05 ), it was statistically correlated with the lymphatic metastasis (P<0.05).Patients with positive PD-L1 expression was sensitive to radiation(P<0.05). Single factor analysis found that the maximum diameter of tumor , radiosensitivity and GTV-T were correlated with PFS (P=0.013,P=0.008,P=0.012) and OS (P=0.004,P=0.039,P=0.025) of ESCC patients. However, PD-L1 expression levels was not correlated with PFS (P=0.953) and OS (P=0.952) of ESCC patients. The results of multifactor analysis showed that the radiosensitivity and the maximum diameter of tumor affected PFS (OR=0.512,95%CI=0.275~0.954,P=0.035) and OS (OR=0.507,95%CI=0.266~0.968, P=0.039) in ESCC patients, respectively.

Conclusion: The level of PD-L1 protein expression in ESCC tissues increased comparing to the normal esophageal mucosa tissues of normal people. PD-L1 may be a novel predictive marker for response to the radiotherapy and metastatic potential in patients with ESCC. But positive PD-L1 cannot as one of prognosis predictors in ESCC patients accomplished curative radiotherapy.

Author Disclosure: D. Ma: None. X. Xie: None. T. Chen: None.

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