Gastrointestinal Cancer

PV QA 1 - Poster Viewing Q&A 1

SU_8_2073 - Clinical Characteristics and Prognosis of Thoracicesophageal Squamous Cell Carcinoma with Abdominal Lymph Node Metastasis

Sunday, October 21
1:15 PM - 2:45 PM
Location: Innovation Hub, Exhibit Hall 3

Clinical Characteristics and Prognosis of Thoracicesophageal Squamous Cell Carcinoma with Abdominal Lymph Node Metastasis
J. Li1, and T. LI2; 1Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, China, 2Department of Radiation Oncology, Fujian Provincial Cancer Hospital,Provincial Clinical College of Fujian Medical University, Fuzhou, China

Purpose/Objective(s): Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor, and the abdominal lymph nodes presented above the celiac trunk were classified as regional lymph nodes in the 7th Edition of American Joint Committee on Cancer (AJCC) guidelines. The aim of this study was to collect cases with abdominal lymph nodes metastasis in ESCC patients and analyzed to reveal their clinical features and prognosis.

Materials/Methods: 181 patients from January 2006 to December 2009 in our hospital underwent the radical esophagectomy and 3-field lymph node dissection were selected, they were pathologically confirmed as ESCC and abdominal lymph node metastasis. Group differences was compared using the chi square test and FISHER exact test for categorical variable data. Survival analysis was generated by Kaplan - Meier method and compared by Log rank test. Cox regression proportional hazards model was used for multivariate analysis.

Results: The left gastric artery lymph node accounting for 58% (105/181) was the most common station in the abdominal lymph node metastatic sites. The overall median survival time was 30 months, and the 1-year, 3-year, 5-year overall survival (OS) rate was 77%, 46%, and 13%, respectively. pN1 stage, pN2 stage, pN3 stage of 1-yea, 3-year, 5-year 0S were 88%, 77%, 64%; 68%, 49%, 20%, 22%, 11%,6%. (P < 0.001) when the number of positive abdominal lymph node was divided into 1, 2 or more than 3 pieces, the 1-, 3- and 5-year OS for each groups were 84%, 57%, 13%; 71%, 47%, 25%; 68%, 27%, 3%. (P=0.001). Univariate analysis showed no significant difference between survival between 1 regional and 2 regional lymph node metastases (p=0.947), but both of them had better prognosis than 3 regional lymph node metastases (P < 0.001). Univariate analysis showed that age, tumor location, pathological T stage, pathological N stage, tumor thickness, tumor thrombus and positive number of abdominal lymph node, positive lymph node ratio and postoperative chemotherapy were prognostic factors. Multiple cox regression revealed that positive lymph node ratio and postoperative chemotherapy were independent prognostic factors for survival.

Conclusion: The number of metastatic lymph nodes, degree of positive lymph node ratio, N stage were related to prognosis when lymph nodes transfer to upper abdominal. While the lymph node metastasis sites had no effect on overall survival for the whole groups that could be regard as the same region. Low positive lymph nodes ratio and postoperative chemotherapy were the powerful and independent prognostic factors related to the outcome.

Author Disclosure: J. Li: None.

Send Email for Jiancheng Li


Assets

SU_8_2073 - Clinical Characteristics and Prognosis of Thoracicesophageal Squamous Cell Carcinoma with Abdominal Lymph Node Metastasis



Attendees who have favorited this

Please enter your access key

The asset you are trying to access is locked. Please enter your access key to unlock.

Send Email for Clinical Characteristics and Prognosis of Thoracicesophageal Squamous Cell Carcinoma with Abdominal Lymph Node Metastasis