Central Nervous System

PV QA 2 - Poster Viewing Q&A 2

MO_3_2490 - Prognostic and functional characterization of AQP1 and AQP4 in patients with glioma based on TCGA database

Monday, October 22
10:45 AM - 12:15 PM
Location: Innovation Hub, Exhibit Hall 3

Prognostic and functional characterization of AQP1 and AQP4 in patients with glioma based on TCGA database
M. H. Chen1, M. Fan1, J. Wang1, J. Wang1, J. Yang1, and J. Lang2; 1Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 2Sichuan Cancer Hospital & Institute, Radiation Oncology Department, Chengdu, China

Purpose/Objective(s): Gliomas are the most common type of primary brain tumors and are the leading cause of cancer-related mortality worldwide. The aquaporins (AQPs) are a family of 13 small hydrophobic integral transmembrane water channel proteins involved in transcellular and transepithelial water movement, transport of fluid and cell migration. Tumor cells expressed AQPs have a positive correlation between histological tumor grade and the AQPs expression. Moreover, AQPs are also involved in tumor edema formation and angiogenesis in several solid and hematological tumors, implying their potentials as novel independent biomarkers for cancer diagnosis and prognosis. However, the prognostic significance of expression profile-based AQP signature for outcome prediction in patients with glioma has not yet been investigated.

Materials/Methods: In this study, the expression and overall survival of AQP1 and AQP4 in brain tumors were first evaluated based on TCGA website GEPIA. Then the detailed histological phenotypes and clinical significance of AQP1 and AQP4 in glioma were evaluated by TCGA website LinkedOmics and UALCAN. With the LinkedOmics website, the co-expressed genes of AQP1 and AQP4 in glioma were analyzed. And the GO and KEGG Pathway enrichment analysis were carried for AQP1 and AQP4 co-expressed genes.

Results: Based on the GEPIA website, we found AQP1 and AQP4 have higher expression in LGG and GBM than adjacent normal tissues, but the higher expression of these two AQPs only shown poor prognosis in LGG not in GBM. With the histological phenotypes and clinical analysis of these two AQPs in LGG, we found AQP1 shown differential expression in patients with different histological type, ethnicity, race and radiation therapy. And AQP4 only showed differential expression in patients with different histological type and race. Higher expression of AQP1 showed poor prognosis in gender, race and tumor grade, but higher expression of AQP4 only showed poor prognosis in gender and tumor grade. Furthermore, KEGG and GO enrichment analysis for co-expressed genes suggested that these two AQPs were all involved in Cell adhension molecular (CAMs) and poly ADP-ribose polymerase (PRAP) signaling pathway.

Conclusion: These findings suggest that higher levels of AQP1 and AQP4 expression are associated with a poor prognosis in brain lower grade glioma in different histological phenotypes. These two AQPs also have potential role in LGG progression, which can be used as biomarkers and therapeutic target. Our results warrant further studies on these AQPs that will improve our understanding of the mechanisms associated with pathogenesis and progression of glioma.

Author Disclosure: M. Chen: None. M. Fan: None.

Send Email for Mei hua Chen


Assets

MO_3_2490 - Prognostic and functional characterization of AQP1 and AQP4 in patients with glioma based on TCGA database



Attendees who have favorited this

Please enter your access key

The asset you are trying to access is locked. Please enter your access key to unlock.

Send Email for Prognostic and functional characterization of AQP1 and AQP4 in patients with glioma based on TCGA database