Head and Neck Cancer
PV QA 2 - Poster Viewing Q&A 2
MO_34_2795 - Examining the Incidence of HPV Positive Oropharynx Cancer in an Ethnically Diverse Population
Monday, October 22
10:45 AM - 12:15 PM
Location: Innovation Hub, Exhibit Hall 3
Examining the Incidence of HPV Positive Oropharynx Cancer in an Ethnically Diverse Population
H. Perlow1, S. J. Ramey2, S. Engel2, D. Kwon3, E. Nicolli4, R. Yechieli5, and S. Samuels5; 1University of Miami Miller School of Medicine, Miami, FL, 2University of Miami; Jackson Health System, Miami, FL, 3Department of Statistics, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL, 4Department of Otolaryngology, University of Miami / Sylvester Comprehensive Cancer Center, Miami, FL, 5Department of Radiation Oncology, University of Miami / Sylvester Comprehensive Cancer Center, Miami, FL
Purpose/Objective(s): The incidence of HPV positive (HPV+) oropharyngeal cancer has increased over the last 40 years. Examining whether this trend is present in an area with a large Hispanic population is important; previous studies have focused on the increased incidence of HPV negative cancer in non-Hispanic Black (NHB) communities, but Hispanic communities have been less studied. This study examined the impact of treatment location, race, ethnicity, and socioeconomic status (SES) on the HPV status of oropharynx cancer patients in an ethnically diverse population.
Materials/Methods: This retrospective analysis included an uninterrupted sequence of non-metastatic oropharyngeal cancer patients treated from 01/01/2014 to 06/30/2016 at either a private academic hospital or adjacent safety-net hospital. Variables analyzed included treatment location, gender, race, ethnicity, cancer type, comorbidity, stage, socioeconomic status, current alcohol use, and smoking history. HPV status was pathologically determined at the time of diagnosis and reported in pathology records which were collected retrospectively. Odds ratios (ORs) and corresponding 95% confidence intervals and p-values were estimated by using a logistic regression model in a univariable analysis (UVA). All p-values were two-sided.
Results: 111 patients were included in this study (17 at the safety-net hospital and 94 at the private academic hospital). 54.1% of patients were non-Hispanic White (NHW), 34.2% of patients were Hispanic, and 9.9% of patients were non-Hispanic Black (NHB). 88.3% of patients had HPV positive disease. 56.8% of patients had a history of smoking. On UVA, safety-net hospital treatment vs. private academic hospital treatment (OR 0.10, p < 0.001), NHB vs. NHW ethnicity (OR 0.09, p = 0.006) and a history of smoking (OR 0.21, P = 0.047) were associated with non-HPV related oropharyngeal cancer. Hispanic vs. NHW ethnicity revealed no significant differences in HPV+ oropharyngeal cancer, and no differences were found based on socioeconomic status.
Conclusion: In this ethnically diverse population, there was an equivalent incidence of HPV+ disease in the Hispanic and NHW populations, but NHB patients had a lower incidence of HPV+ disease compared to NHW patients. There was also a decreased incidence of HPV+ oropharyngeal cancer in the safety-net hospital. Additionally, approximately ½ the HPV+ patients are smokers. Follow up and outcome data are needed to determine whether HPV positivity predicts for improved prognosis in this population.
Author Disclosure: H. Perlow: None. S.J. Ramey: Travel Expenses; Intellisphere. S. Engel: None. D. Kwon: None. E. Nicolli: None. R. Yechieli: None.