Head and Neck Cancer

PV QA 2 - Poster Viewing Q&A 2

MO_33_2772 - 5-Fu Continuously Pump Infusion Via Superficial Temporal Artery Cannula for High T Staged Nasopharyngeal Carcinoma: A Phase I Clinical Trial

Monday, October 22
10:45 AM - 12:15 PM
Location: Innovation Hub, Exhibit Hall 3

5-Fu Continuously Pump Infusion Via Superficial Temporal Artery Cannula for High T Staged Nasopharyngeal Carcinoma: A Phase I Clinical Trial
X. Li1, W. J. Bo2, P. Ren3, H. Pang4, Q. Wen5, and S. Lin4; 1Department of Oncology,the Affilicated Hospital of SouthWest Medical University, Luzhou, China, 2Department of Oncology,Affiliated Hospital of SouthWest Medical University, LuZhou, China, 3The Affiliated Hospital of Southwest Medical University, Luzhou, China, 4Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, China, 5Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China

Purpose/Objective(s): The purpose of this article is to present the maximum tolerated dose(MTD) , adverse events, and efficacy of 5-Fu continuously pump infusion via superficial temporal artery cannula for high T staged nasopharyngeal cancinoma.

Materials/Methods: 29 patients with histologically confirmed nasopharyngeal cancinoma were eligible in the phase I trial. They received induction chemotherapy which consisted of cisplatin (20 mg/m2/d ,days 1-5) and 5 FU(pump infused continuously for 120 hours in different dose gradient),while the regimen was administrated via superficial temporal artery. The MTD of 5-Fu was determined by detecting increasing doses in different groups until the highest dose with acceptable toxicities were obtained. Dose-limiting toxicity (DLT) was defined as any grade 4 or more serious toxicity,and the trial was closed when the rate of DLT exceeded 25%.The total length of the chemotherapy cycle was 21 days. Followed with 2 circles chemotherapy, the radical radiotherapy was conducted. We assessed efficacy, toxicity and life quality, especially on the oral mucositis and radiation brain damage.

Results: There were six dose gradients of 5-Fu,including 200mg/m2(6 cases), 250mg/m2(6 cases), 300mg/m2(5 cases), 350mg/m2(5 cases), 400mg/m2(5 cases),450mg/m2 (5 cases)and 500mg/m2(2 cases). No toxicities of grade III or above was observed in the group with dose of less than 350 mg/m2.In the dose group of 400mg/m2,there were 2 patients developed grade III oral mucositis.And 1 cases was found with grade IV toxicity in the 450mg/m2 group.Sadly,the 2 patients enrolled in the dose group of 500mg/m2 all were observed the grade IV toxicity mainly included oral mucositis,so the test was terminated. The overall response rates for the primary mass and lymph nodes were 93% and 100%, respectively. The 5-year overall survival (OS) was 80%.The 5-years progression-free-survival(PFS) was 73.3%.The MTD of 5-Fu was 450mg/m2,we also determined the optimal dose was 400mg/m2 according to the response,toxicities and survival.

Conclusion: 5-Fu continuously pump infusion via superficial temporal artery cannula results in promising efficacy and good tolerability in patients with high T staged nasopharyngeal cancinoma,the MTD was 450mg/m2.

Author Disclosure: X. Li: None. W.J. Bo: None. P. Ren: None.

Send Email for Xiang Li


Assets

MO_33_2772 - 5-Fu Continuously Pump Infusion Via Superficial Temporal Artery Cannula for High T Staged Nasopharyngeal Carcinoma: A Phase I Clinical Trial



Attendees who have favorited this

Please enter your access key

The asset you are trying to access is locked. Please enter your access key to unlock.

Send Email for 5-Fu Continuously Pump Infusion Via Superficial Temporal Artery Cannula for High T Staged Nasopharyngeal Carcinoma: A Phase I Clinical Trial