Central Nervous System

PV QA 2 - Poster Viewing Q&A 2

MO_8_2675 - Outcome analysis and impact of prognostic factors on survival of 111 Adult Medulloblastoma patients : A long term single institutional study.

Monday, October 22
10:45 AM - 12:15 PM
Location: Innovation Hub, Exhibit Hall 3

Outcome analysis and impact of prognostic factors on survival of 111 Adult Medulloblastoma patients : A long term single institutional study.
R. A. Patil1, R. Jalali2, and T. Gupta2; 1TATA MEMORIAL CENTER, MUMBAI, India, 2Tata Memorial Centre, Mumbai, India

Purpose/Objective(s): Being a rare disease, adult medulloblastoma is always a clinical challenge in spite of years of extensive research. The principal aim of this report is to study demographics, clinical parameters, pathological features, molecular subtypes and their impact on clinical outcome.

Materials/Methods: This was a retrospective study of 111 patients aged > 15 years diagnosed with medulloblastoma (2006-2016) treated with uniform institutional protocol. The medial follow up of this study was 37 months.

Results: Median age of presentation was 25 years with male to female ratio of 3.1:1. Location of disease was lateral in 77 % of patients with the most common histologies being desmoplastic and classical. Molecular data of 51 patients were available. The most common molecular subtype was SHH subtype which accounts for 69%. 47% of the relapses took place after 2 years with a majority of relapses in local tumour bed. 2,5 and 10 year disease free survival were 74 %, 56.6% and 32.2% respectively whereas 2, 5 and 10 years overall survival were 87%, 68.8%, 46.2% respectively. Prognostic factors which had a statistically significant impact on DFS were presence of residual disease, high risk category, presence of anaplasia, large cell histology and metastasis at presentation while residual disease, high risk group achieved statistically significant values for predicting long term OS.

Conclusion: The present analysis should serve as suitable benchmark to design appropriate risk stratification to improve outcomes in this subset of adult medulloblastoma patients.

Author Disclosure: R.A. Patil: None. R. Jalali: None. T. Gupta: None.

Send Email for Roshankumar Patil


Assets

MO_8_2675 - Outcome analysis and impact of prognostic factors on survival of 111 Adult Medulloblastoma patients : A long term single institutional study.



Attendees who have favorited this

Please enter your access key

The asset you are trying to access is locked. Please enter your access key to unlock.

Send Email for Outcome analysis and impact of prognostic factors on survival of 111 Adult Medulloblastoma patients : A long term single institutional study.