Head and Neck Cancer

PV QA 2 - Poster Viewing Q&A 2

MO_24_2505 - Radiomics Prediction of Radiation Treatment Outcomes in Oropharyngeal Cancer: A Clinical and Image Repository in Concert with the Cancer Imaging Archive (TCIA)

Monday, October 22
10:45 AM - 12:15 PM
Location: Innovation Hub, Exhibit Hall 3

Radiomics Prediction of Radiation Treatment Outcomes in Oropharyngeal Cancer: A Clinical and Image Repository in Concert with the Cancer Imaging Archive (TCIA)
H. Elhalawani1, A. S. Mohamed2, S. Mulder3, A. Grossberg4, K. E. Smith5, G. B. Gunn2, S. J. Frank2, D. I. Rosenthal2, A. S. Garden2, and C. D. Fuller6; 1Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 2The University of Texas MD Anderson Cancer Center, Houston, TX, 3Abilene Christian University, Abilene, TX, 4Oregon Health and Science University, Portland, OR, 5University of Arkansas for Medical Sciences, Department of Biomedical Informatics, Little Rock, AR, 6University of Texas Graduate School of Biomedical Sciences, Houston, TX

Purpose/Objective(s): There is an unmet need for integrating quantitative imaging biomarkers into current risk stratification tools. To explore the correlation between radiomics features –alone or in combination with clinical prognosticators- and tumor outcome, we retrieved clinical meta-data and matched baseline contrast-enhanced computed tomography (CECT) scans from a single institution, institutional review board (IRB)-approved cohort of 495 oropharyngeal cancer (OPC) patients. We opted to publicly share this large curated data set and subsequent radiomics analytical outcome via The Cancer Imaging Archive (TCIA) to serve as a resource for optimized standardization in the radiomics field.

Materials/Methods: Diagnostic CECT images were acquired at our institution between 2005 and 2012 for 495 OPC patients (prior to any active intervention) in Digital Imaging and Communications in Medicine (DICOM) format. Expert radiation oncologists manually segmented primary and nodal disease gross volumes (GTVp & GTVn). Structure sets were named per the American Association of Physicists in Medicine (AAPM) TG-263 recommendations, then retrieved in DICOM RTSTRUCT format. Matched patient, disease, treatment and outcomes data were obtained. Radiomics analysis was performed using an open-source institutionally-developed software that runs on a computer algorithm. Protected health information (PHI) was removed from all DICOM elements in compliance with the DICOM standards committee P.S. 3.15 Annex E, Attribute Confidentiality Profile using the Radiological Society of North America clinical trial processor (RSNA CTP). TCIA’s curation process ensures the DICOM data is free of PHI and all linkages between CT and structure sets are correct. Following curation the data was archived in TCIA as a permanent open-access collection named “HNSCC”.

Results: Anonymized data for 495 OPC patients will be made publicly available from TCIA as downloadable DICOM files (N=**), clinical data, and processed outputs, i.e. tumor segmentations and extracted radiomics features. All data attributes can be cross-referenced via the same anonymized subject IDs. We prepared a data dictionary that specifies clinical data attributes, definitions and possible variables per North American Association of Central Cancer Registries (NAACCR) guidelines.

Conclusion: Large-scale data curation-anonymization-transfer workflows, as well as advanced image registration algorithms and common ontology data dictionaries, are unmet needs for joint machine-learning/radiomics research projects. If these resources are paired with large, curated data sets, like those provided via open-access mega-data repositories, like TCIA, the potential benefits include identification of imaging-derived radiomics signatures associated with treatment outcomes and normal-tissue complications across various head and neck epidemiologic cohorts.

Author Disclosure: H. Elhalawani: Employee; MD Anderson Cancer Center. A.S. Mohamed: None. S. Mulder: None. K.E. Smith: Research Grant; University of Arkansas for Medical Sciences. G.B. Gunn: Associate Medical Director; MD Anderson Cancer Center - Proton Therapy. S.J. Frank: Research Grant; C4 Imaging, ELEKTA, U19. Founder and Director; C4 Imaging. Honoraria; ELEKTA, Varian Medican Systems, Inc. Advisory Board; Varian Medican Systems, Inc. Stock; C4 Imaging. Royalty; C4 Imaging. Patent/License Fees/Copyright; C4 Imaging. Chairman; American Brachytherapy Society. Director; C4 Imaging. Director-at-large; North America Skull Base Society. D.I. Rosenthal: None. A.S. Garden: None. C.D. Fuller: Research Grant; National Institutes of Health, National Science Foundation, Elekta AB. Grant funding; Elekta AB. Honoraria; Nederlandse Organisatie voor Wetenschappelijk Onde. Consultant; Elekta AB, Nederlandse Organisatie voor Wetenschappelijk Onde. Travel Expenses; Elekta AB, Nederlandse Organisatie voor Wetenschappelijk Onde. Reviewer; Radiological Society of North America. Associate Editor; Radiographics. Data Management Task Force Committee Member; MR-LinAc Consortium. Member; National Cancer Institute. Task Group Member; American Association of Physicists in Medicine.

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