Head and Neck Cancer

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MO_27_2639 - Patterns of Local or Regional Recurrence after Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma

Monday, October 22
10:45 AM - 12:15 PM
Location: Innovation Hub, Exhibit Hall 3

Patterns of Local or Regional Recurrence after Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma
M. Kang1, Y. Lu2, B. Yu3, X. Liao4, M. Xu4, P. Zhou5, Z. Yang4, Y. Bin4, and R. Wang6; 1Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China, 2Department of Radiation Oncology, the Fourth Affiliated Hospital of Guangxi Medical University, liu zhou, China, 3Department of Radiation Oncology, the People’s Hospital of Liuzhou, liuzhou, China, 4Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, nanning, China, 5Department of Radiation Oncology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China, 6Guangxi tumor radiation therapy clinical medical research center, nanning, China

Purpose/Objective(s): Intensity-modulated radiotherapy(IMRT) becomes primary treatment for nasopharyngeal carcinoma (NPC). However, local and regional recurrences of NPC are important reasons of failure. The aim is to evaluate patterns of local or regional recurrence of NPC in patients that had been treated with IMRT.

Materials/Methods: We performed a retrospective analysis of 645 patients with NPC at three treatment centers in China, from January 2009 to December 2011. All patients had untreated, non-metastatic NPC prior to receiving IMRT. The Kaplan-Meier method was used to calculate patient survival rates, and log-rank testing was used to compare survival differences. Univariate analysis and Cox proportional hazard analysis were performed to explore treatment failure patterns and risk factors for local or regional recurrence after radiotherapy.

Results: With a mean follow-up of 62 months (11-95), the OS, LRFS, RRFS and DMFS were calculated to be 84.2%, 90.1%, 94.4% and 82.8%. The 1-year, 3-year, and 5-year local recurrence rates were calculated to be 0.9%, 6.5%, and 9.0%. The 1-year, 3-year, and 5-year locoregional control rates were calculated to be 99.1%, 93.4%, and 90.1%. In the 60 patients with a recurrence, the in-field, Marginal-field, and out-field recurrence rates were 93.3% (56/60), 5.0% (3/60), and 1.7% (1/60). Failures occurring within the first three years after treatment accounted for 81.7% (49/60) of all failures.

Conclusion: IMRT for NPC patients was shown to result in excellent locoregional control. Most of the recurrences happened in the first three years after treatment. The in-field recurrences were the most common pattern for locoregional failure in NPC.

Author Disclosure: M. Kang: None. Y. Lu: None. Y. Bin: None.

Min Kang, PhD

Biography:
Min Kang, female,Ph.D., Associate Professor, Master Tutor. Research direction: Basic and clinical investigation of nasopharyngeal carcinoma. The reviewer for several academic journals, and the member of the editorial board of Chinese Journal of Metastatic Tumors.
The member of the First Chinese Tumor Radiotherapy Cooperation Group of the World Association of Chinese Oncologists, the member of the Tumor Radiotherapy Professional Committee of the Wu Jieping Medical Foundation, the director of the West China Society of Therapeutic and Radiation Oncology, the standing committee member of the Youth Committee of the West China Society of Therapeutic and Radiation Oncology, the member of the Tumor Nutrition Professional Committee of the China Anti-aging Promoting Association, the member of the Translational Medicine Branch of the Medical Doctor Association of the Overseas-educated Scholars Association of China, the standing committee member and the secretary of the Radiation Oncology Branch of the Guangxi Medical Association, the vice-chairmen and the secretary of the Youth Committee of the Radiation Oncology Branch of the Guangxi Medical Association, the member and the secretary of the Nasopharyngeal Carcinoma Group of the Radiation Oncology Branch of the Guangxi Medical Association, the associate director and the secretary of the Nasopharyngeal Carcinoma Group of the Oncology Branch of the Guangxi Medical Association, the Secretary-general of the Guangxi Union of Oncology Management, and the vice-chairmen and the secretary of the Nasopharyngeal Carcinoma Professional Committee of the Guangxi Union of Oncology Management.
In the past five years, published over 40 academic articles, as the first/corresponding author in 15 articles (SCI), presided 3 national projects, 2 provincial projects from the Guangxi Natural Science Foundation, and won the third prize in the Science and Technology Progress Award of Guangxi, and the first prize in the Promotion Award for the Appropriate Medical and Health Technique of Guangxi.

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