Hematologic Cancer

PV QA 2 - Poster Viewing Q&A 2

MO_42_2708 - Bone Event: A New Surrogate to Solitary Plasmacytoma

Monday, October 22
10:45 AM - 12:15 PM
Location: Innovation Hub, Exhibit Hall 3

Bone Event: A New Surrogate to Solitary Plasmacytoma
G. P. Mauro1, H. D. A. Carvalho1, P. Neffa1, G. A. Martinez1, and R. C. Villar2; 1University of Sao Paulo, Sao Paulo, Brazil, 2Centro Infantil Boldrini, Campinas, Brazil

Purpose/Objective(s): In the past decades, few developments had been achieved in the treatment of solitary bone plasmacytoma. The incidence of bone events (BE) and their morbidity have never been described. In addition, the correlation of BE, as an end-point, with overall survival (OS) and progression to multiple myeloma free-survival (PMFS) of patients with solitary plasmacytoma was never studied.

Materials/Methods: Fifty-nine patients treated from 2008 to 2017 were retrospectively assessed. All had biopsy proven solitary plasmacytoma that was treated with radiotherapy (RT) alone to the index lesion, available clinical information, and at least 6 months follow-up or until death. BE were described as at least one of the following events in the index bone: fractures, indication of surgery after RT, chronic pain, loss of function of the limb after RT or osteomyelitis.

Results: Mean age at diagnosis was 57.3 years (18-80); 67.8% were male. There were 15 deaths in this population. Mean OS, bone event free-survival (BEFS), local progression-free survival (LPFS) and PMFS were 41, 36, 37 and 19 months, respectively. In our sample, the only factor that correlated to BEFS was abnormal LDH (p=0.009). Factors that correlated to PMFS were BEFS (p=0.008) and age>55y (p=0.044). The only factor correlated with OS was BEFS (p=0.029). BE was independently associated to both PMFS and OS in multivariate analysis.

Conclusion: BE were associated not only with morbidity to solitary plasmacytoma patients, but also with survival in this cohort. This variable should be assessed in prospective trials.

Author Disclosure: G.P. Mauro: None. H. Carvalho: None. P. Neffa: None. G.A. Martinez: None.

Geovanne Mauro, MD

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