Sarcoma and Cutaneous Tumors

PV QA 2 - Poster Viewing Q&A 2

MO_20_2560 - Married Patients With Soft Tissue Sarcoma Have Improved Overall Survival Compared To Single Patients

Monday, October 22
10:45 AM - 12:15 PM
Location: Innovation Hub, Exhibit Hall 3

Married Patients With Soft Tissue Sarcoma Have Improved Overall Survival Compared To Single Patients
B. Eastman1, L. Wootton2, D. S. Hippe3, L. M. Halasz1, E. Y. Kim1, M. Nyflot1, and M. B. Spraker1; 1University of Washington, Department of Radiation Oncology, Seattle, WA, 2University of Washington, Seattle, WA, 3University of Washington, Department of Radiology, Seattle, WA

Purpose/Objective(s): Treatment for soft tissue sarcoma (STS) includes extensive surgical resection and intensive radiation ± chemotherapy that may require social and economic support. Previous studies have found that marital and income status are important to survival in many cancers. In this study, we hypothesized that socioeconomic factors are independent predictors for overall survival in STS patients.

Materials/Methods: We performed a retrospective chart review of 712 patients with biopsy-confirmed STS treated at our institution. Patients younger than 18 years of age were excluded. Clinical stage, pathological grade, treatment modality, permanent residence zip code, marital and employment status were obtained from the electronic medical record. Average income was determined based on IRS data for the patient’s permanent residence zip code. Overall survival (OS) was defined as the time from pathologic diagnosis to death from any cause. The relationship between clinical and socioeconomic variables (marital status, income, employment status) and OS was evaluated first using univariate analysis. Variables with p<0.05 were included in a multivariate model.

Results: The median follow-up was 3.9 years (range: 8 days to 19.9 years). Median OS was 10.8 years. On multivariate analysis, married patients had better OS compared to single patients (HR 1.32, p=0.049), but employment status (HR 0.84, p=0.45) and income level (HR 0.96, p=0.6) were not significantly associated with OS. Furthermore, higher grade (p<0.001), tumor size greater than 5 cm (p=0.013), increasing age (p=0.013), and the presence of metastases (p<0.001) were negatively associated with survival.

Conclusion: This study found that married patients had improved overall survival compared to single patients even after adjusting for known negative clinical prognostic factors. This may reflect improved support for married patients undergoing intensive treatment. Further studies will investigate how to improve treatment outcomes for patients with negative socioeconomic prognostic factors.

Author Disclosure: B. Eastman: None. L.M. Halasz: Research Grant; Fred Hutch/Univ of Washington Cancer Consortium. E.Y. Kim: Annual Meeting Scientific Committee Chair; RSNA. M.B. Spraker: None.

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