Andrea Lo, MD, BS
Presentation(s):
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TU_23_3096 - Long-term Health-related Quality of Life in Survivors of Intracranial Germ Cell Tumor
Tuesday, October 23
1:00 PM – 2:30 PM
Pediatric Cancer
PV QA 3 - Poster Viewing Q&A 3
Purpose/Objective(s): The purpose of this study is to investigate health-related quality of life (HRQOL) in survivors of intracranial germ cell tumors (IGCT). We hypothesize that HRQOL is lower for IGCT survivors compared to the general population.
Materials/Methods: Survivors of IGCT were invited to attend the clinic and were asked to complete the 36-Item Short Form Survey Instrument (SF-36). The SF-36 is scored from 0-100, with a higher number representing a more favorable HRQOL. SF-36 scores of the study cohort were compared with that of the general population.
Results: The study cohort consisted of 12 survivors of IGCT, 6 males and 6 females. Median age was 13 years at diagnosis (range, 10-18), and 26 years at time of study (range, 7-34). Median follow-up was 11 years. Five patients had germinomas, and 7 had non-germinomatous germ cell tumors. All 12 patients received radiation therapy (RT), 10 to the craniospinal axis, 1 to the whole ventricles and 1 to the tumor bed alone. Nine patients received chemotherapy. Mean SF-36 scores and Canadian normative data are shown in the below table.
SF-36 | Mean scores (standard deviation [SD]) | |
Study Cohort | Canadian normative data | |
Physical functioning | 67.9 (33.2) | 83.5 (21.2) |
Role limitations due to physical health | 58.3 (37.4) | 78.7 (35.5) |
Bodily pain | 74.2 (33.4) | 73.3 (23.3) |
General health | 57.1 (24.0) | 76.4 (17.7) |
Vitality | 43.1 (18.4) | 62.9 (18.4) |
Social functioning | 62.5 (32.0) | 84.3 (20.7) |
Role limitations due to emotional problems | 77.8 (32.8) | 81.2 (33.7) |
Mental health | 74.3 (15.3) | 76.1 (15.7) |
Conclusion: Long-term HRQOL for survivors of IGCT is lower than that of the overall population, particularly in vitality, general health, and social functioning. Physical and psychosocial supports should be considered for IGCT survivors. Larger studies would be worthwhile to determine factors associated with HRQOL, which may improve treatment decision-making and informed consent for patients and families affected by IGCT.
TU_23_3096 - Long-term Health-related Quality of Life in Survivors of Intracranial Germ Cell Tumor
Tuesday, October 23
1:00 PM – 2:30 PM
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