Radiation Physics

PV QA 3 - Poster Viewing Q&A 3

TU_12_3234 - A Computational Study Investigating the Optimization of Tumor Treating Fields Delivery When Treating Ovarian Cancer

Tuesday, October 23
1:00 PM - 2:30 PM
Location: Innovation Hub, Exhibit Hall 3

A Computational Study Investigating the Optimization of Tumor Treating Fields Delivery When Treating Ovarian Cancer
A. Naveh1, O. Yesharim2, O. Farber3, N. Urman1, H. S. Hershkovich1, E. Kirson1, Z. Bomzon1, and U. Weinberg1; 1Novocure, Haifa, Israel, 2novocure, haifa, Israel, 3Novocure ltd., Haifa, Israel

Purpose/Objective(s): Tumor Treating Fields (TTFields) are alternating electric fields in the intermediate frequency (100-300 kHz) known to inhibit the growth of solid tumors. TTFields are delivered through transducer arrays non-invasively to the tumor region. In-vitro studies show that TTFields’ efficacy is intensity-dependent, with a threshold intensity of about 1 V/cm below which the effect of the fields on the cells decreases significantly. This suggests that when treating with TTFields, it is important to optimize array placement to maximize field intensity at the tumor bed. A phase II clinical trial (INNOVATE) has demonstrated the feasibility and safety of TTFields for the treatment of advanced ovarian cancer. A Phase III trial in ovarian cancer is under development. In order to develop strategies for optimizing array placement when treating ovarian cancer, we performed a simulation-based study investigating how altering array positions on the abdomens of female computational phantoms influences the field distribution within their bodies. Here we report on the results of this study.

Materials/Methods: To simulate delivery of TTFields to the abdomen, we used realistic computerized model of three human females with Body Mass Indices (BMI) of 21, 26 and 30. Two pairs of transducer arrays were placed on the skin of the models: one pair of arrays was placed on the abdomen and while the second pair of arrays was placed on the lateral aspects of the computerized models. To deliver TTFields, electric currents of 4A peak-to-peak at frequency of 200 KHz were delivered to the arrays. The location of the arrays on the models skins was altered systematically, and the field distributions within standard abdominopelvic regions were analyzed.

Results: In all models, the electric field was confined to the region located between the transducer arrays. In all simulations, the field was heterogeneous with intensity exceeding 1 V/cm in significant portions of the volumes located between the transducer arrays.

Conclusion: The results suggest that by carefully choosing the position of the transducer arrays, it is possible to effectively deliver TTFields to target regions throughout the abdomen of female subjects regardless of BMI. This work forms the basis for developing optimal strategies for delivering TTFields when treating ovarian cancer.

Author Disclosure: A. Naveh: Stock; Novocure. Stock Options; Novocure. O. Yesharim: Stock; Novocure. Stock Options; Novocure. O. Farber: Stock; Novocure. Stock Options; Novocure. H.S. Hershkovich: Stock; Novocure. Stock Options; Novocure. E. Kirson: Stock; Novocure. Stock Options; Novocure. chief scientific officer; novocure.

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