Non-malignant

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TU_34_3018 - Radiation Therapy in the Treatment of Primary or Recurrent Unresectable Desmoid Tumors of the Neck

Tuesday, October 23
1:00 PM - 2:30 PM
Location: Innovation Hub, Exhibit Hall 3

Radiation Therapy in the Treatment of Primary or Recurrent Unresectable Desmoid Tumors of the Neck
X. Niu1, and C. Hu2; 1Departments of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China, Shanghai, China, 2Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

Purpose/Objective(s): Desmoid tumors (aggressive fibromatosis) are locally aggressive nonmalignant soft tissue tumors, which frequently recur after therapy. Surgery is the mainstay treatment in resectable cases. Few studies have reported the effects of other treatments in one lesion when surgery is not possible or would cause notable functional impairment. Our aim was to examine the outcome of radiotherapy (RT) in the treatment of primary or recurrent unresectable desmoid tumors of the neck.

Materials/Methods: A retrospective analysis was performed on 30 patients between 1/2008 and 12/2017, with 3 primary and 27 recurrent unresectable desmoid tumors of the neck. Response evaluation was reassessed according to RECIST criteria 1.1. All cases were reviewed by our Department of Pathology. Acute and late side effects of radiotherapy were recorded and graded according to the Radiation Oncol­ogy Group (RTOG) acute and late morbidity scoring criteria.

Results: The median follow-up time was 47.5 months (range 2-126 months). Radiotherapy dose varied from 50 to 66Gy (median 60 Gy, 23/30 patients) with all fraction size of 2 Gy. The objective response rate (ORR: CR or PR) to definitive RT was 56.7% (17/30 patients). Three patients developed local recur­rence after RT, which occurred out-of-target. On univariate analysis, ORR was significantly influenced by tumor size (<5 cm vs. ≥5 cm) (p = 0.023). Age (≤ 40 vs. >40 years) (p = 0.804), gender (p = 0.629) and RT dose (<60, =60 vs. >60 Gy) (p = 0.613) were not significantly as­sociated with ORR. The most common acute side effect of the radiation-related complication was grade 1-2 skin toxicity.

Conclusion: Radiotherapy is a valuable option in the management of primary or recurrent unresectable desmoid tumors of the neck when surgical resection is not feasible. According to our results, radiotherapy is especially beneficial in tumor size <5cm. The complications of the radiation-related are acceptable.

Author Disclosure: X. Niu: None. C. Hu: None.

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