Radiation Physics

PV QA 3 - Poster Viewing Q&A 3

TU_16_3268 - Adaptive Deformable Registration and Fusion for Fractionated Stereotactic Radiosurgery Using a Small Animal Irradiator

Tuesday, October 23
1:00 PM - 2:30 PM
Location: Innovation Hub, Exhibit Hall 3

Adaptive Deformable Registration and Fusion for Fractionated Stereotactic Radiosurgery Using a Small Animal Irradiator
P. J. Black1, D. Smith2, K. R. Chaudhary1, E. P. Xanthopoulos3, C. Chin1, C. S. Spina4, M. Hwang1, M. Mayeda1, Y. F. Wang1, E. P. Connolly5, T. J. C. Wang1, C. S. Wuu1, T. Hei1, S. K. Cheng6, and C. C. Wu1; 1Department of Radiation Oncology, Columbia University Medical Center, New York, NY, 2Columbia University College of Physicians and Surgeons, New York, NY, 3Columbia University Medical Center Department of Radiation Oncology, New York, NY, 4Boston University School of Medicine, Boston, MA, 5Dept of Radiation Oncology, Columbia University Medical Center, New York, NY, 6Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY

Purpose/Objective(s): To implement software-based image fusion and adaptive deformable registration to enable treatment planning for preclinical murine models of fractionated stereotactic radiosurgery (fSRS) using the Small Animal Radiation Research Platform (SARRP).

Materials/Methods: C57BL6 mice underwent three unique cone-beam computed tomography (CBCT) scans: two in the prone position and a third supine. A single T1-weighted post-contrast Magnetic Resonance Imaging (MRI) series of a metastatic brain tumor was selected for MRI-to-CBCT registration and gross tumor volume (GTV) identification. Two arms were compared: Arm 1, where we performed three individual MRI-to-CBCT fusions using rigid registration, contouring GTVs on each, and Arm 2, where we performed MRI-to-CBCT fusion and contoured GTV on the first CBCT followed by software-based adaptive registration. The first CBCT and associated GTV were exported from dose planning software intoan imaging registration platform. The second and third CBCTs were exported similarly, along with associated GTVs (Arm 1). In Arm 2, the first (prone) CBCT was fused separately to the second (prone) and third (supine) CBCTs. Deformable registrations were performed on initial CBCTs, applying resulting matrices to the contoured GTV. Consistency of GTVs were compared between Arms 1 and 2.

Results: Comparing GTV overlays using repeated MRI fusion and GTV delineation (Arm 1) versus those of software-based CBCT and GTV adaptive fusion (Arm 2), mean deviations ± standard deviation in the axial, sagittal, and coronal planes were 0.46±0.16, 0.46±0.22, and 0.37±0.22 mm for prone-to-prone and 0.52±0.27, 0.52±0.36, and 0.68±0.31 mm for proneto-supine adaptive fusions, respectively.

Conclusion: Adaptive fusion of CBCTs and contoured volumes allows for efficient fSRS planning using a single MRI-to-CBCT fusion. This technique can be immediately implemented on current SARRP systems, facilitating advanced preclinical treatment paradigms using existing clinical treatment planning software.

Author Disclosure: P.J. Black: None. D. Smith: None. K.R. Chaudhary: None. E.P. Xanthopoulos: None. C. Chin: None. M. Mayeda: None. E.P. Connolly: Employee; Celgene. Research Grant; Eisai, Merck. Advisory Board; Eisai. T.J. Wang: Honoraria; Elekta, Wolthers Kluwer. Consultant; Abbvie, Merck, Doximity, Elekta. Advisory Board; American Cancer Society North Jersey, AstraZeneca. Travel Expenses; Abbvie, AstraZeneca, Elekta. Stock Options; Doximity. C. Wuu: None. T. Hei: President-elect; Radiation Research Society. C. Wu: None.

Paul Black, PhD

Disclosure:
No relationships to disclose.

Presentation(s):

Send Email for Paul Black


Assets

TU_16_3268 - Adaptive Deformable Registration and Fusion for Fractionated Stereotactic Radiosurgery Using a Small Animal Irradiator



Attendees who have favorited this

Please enter your access key

The asset you are trying to access is locked. Please enter your access key to unlock.

Send Email for Adaptive Deformable Registration and Fusion for Fractionated Stereotactic Radiosurgery Using a Small Animal Irradiator