Breast Cancer

PV QA 4 - Poster Viewing Q&A 4

TU_9_3408 - A Reliable Nomogram for Predicting Overall Survival in Patients with Triple-Negative Breast Cancer

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

A Reliable Nomogram for Predicting Overall Survival in Patients with Triple-Negative Breast Cancer
M. Ma1, X. S. Gao1, and N. Jing2; 1Department of Radiation Oncology, Peking University First Hospital, Beijing, China, 2Department of Radiation Oncology, Shanxi Cancer Hospital, Taiyuan City, China

Purpose/Objective(s): Currently, there is no reliable nomogram to predict overall survival (OS) for patients with triple-negative breast cancer (TNBC). The purpose of this study was to develop a prognostic nomogram from a cohort of TNBC patients by correlating clinical characteristics and pathological parameters with OS.

Materials/Methods: We retrospectively analysed 242 eligible TNBC patients treated between 2009 and 2012 at our institution. Age, family history, menopause status, operative type, tumour size, tumour histological grade, the number of axillary metastatic lymph node, postoperative pathological TNM stage, vascular invasion, perineural invasion, CK5/6 expression status, Ki67 index, and E-cadherin expression status were analysed. Predictors were used in a multivariable logistic regression analysis to develop a nomogram that predicts OS. The predictive accuracy and discriminative ability of the nomogram were determined by the concordance index (C-index) with calibration curves, and the receiver operating characteristic (ROC) curves, respectively. Analyses were performed with statistical software packages.

Results: The median follow-up time was 70.73 months (range, 7.20–95.93 months) and the median age was 51 years (range, 29–69 years). Of the study patients, 32.6%, 42.6%, and 24.8% had disease stage I, II, III, respectively. The 3- and 5-year OS for all patients were 86.5% (95% CI, 82.2–90.8%) and 81.1% (95% CI, 76.2–86.0%), respectively. Multivariate analyses demonstrated that age, tumour size, the number of axillary metastatic lymph nodes, and E-cadherin expression were independent risk factors for OS. These predictors were used in the nomogram to estimate the 3- and 5-year OS. Calibration curves for probabilities showed good agreement between prediction by the nomogram and actual observation (C-index = 0.821).

Conclusion: Using clinicopathological information, we produced a prognostic nomogram that accurately predicts the 3- and 5-year OS for patients with TNBC.

Author Disclosure: M. Ma: None. X. Gao: None. N. Jing: None.

Mingwei Ma, MD

Biography:
Mingwei Ma, M.D., Peking University First Hospital
EDUCATION
Resident (Sep. 2015 to now)
Peking University First Hospital and Cancer Hospital Chinese Academy of Medical Sciences
Graduate (Sep. 2012 – 2015)
Master in Radiation Oncology
Peking University First Hospital
Peking University Health Science Center
Undergraduate (Sep. 2007-Sep. 2012)
Bachelor in Clinical Medicine and Radiation Medical Science
Hebei Medical University
SOCIAL EXPERIENCES
Working as secretariat of Academic Forum of Radiation Oncology in Beijing in 2013 and 2014.
Facilitating organizing the 5th China-Japan-Korea Trilateral Symposium on Radiation Oncology in Chengdu, China.
Participated in data extraction and audit in CHINA PEACE Retrospective Study taken by Chinese Academy of Medical Science, Fuwai Hospital.
PUBLICATIONS
Ma M, Gao X, Yu H, Androgen-like effects of Cordyceps sinensis and its impact on the radiosensitivity of VCaP prostate cancer cells, 2015; 24: 344-348
Ma M, Zhu H, Zhang C et al. "Liquid biopsy"-ctDNA detection with great potential and challenges. Ann Transl Med 2015; 3: 235.

Presentation(s):

Send Email for Mingwei Ma


Assets

TU_9_3408 - A Reliable Nomogram for Predicting Overall Survival in Patients with Triple-Negative Breast Cancer



Attendees who have favorited this

Please enter your access key

The asset you are trying to access is locked. Please enter your access key to unlock.

Send Email for A Reliable Nomogram for Predicting Overall Survival in Patients with Triple-Negative Breast Cancer