Lung Cancer

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TU_30_3615 - Apatinib Alone or Combined with Radiation Therapy As a Salvage Treatment in Advanced Non-Small Cell Lung Cancer Failed from Two or More Lines of Prior Chemotherapy or Molecular Targeted Therapy

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

Apatinib Alone or Combined with Radiation Therapy As a Salvage Treatment in Advanced Non-Small Cell Lung Cancer Failed from Two or More Lines of Prior Chemotherapy or Molecular Targeted Therapy
T. Li1, J. Lv2, Q. Wang3, Y. Fan3, J. Wang4, Y. Song5, L. Liang5, and L. Wu5; 1Department of Radiation Oncology, Sichuan Cancer Hospital& Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, chengdu, China, 2Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, chengdu, China, 3Department of Radiation Oncology, Sichuan Cancer Hospital& Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 4sichuan cancer hospital, chengdu, China, 5sichuan cancer hospital, chengdu, China

Purpose/Objective(s): The efficacy of third-line or beyond chemotherapy in advanced non-small cell lung cancer (NSCLC) patients is low. Apatinib, as a novel small molecule antiangiogenic drug, has demonstrated satisfactory anticancer activity across a broad range of malignancies. The aim of this study is to evaluate the efficacy and safety of apatinib alone or combined with radiotherapy in patients with advanced NSCLC after second-line or beyond treatment failure.

Materials/Methods: This study comprised 81 patients with advanced NSCLC who had progressed after second-line or beyond treatment. Patients received apatinib alone or combined with radiotherapy between August 2015 and November 2017. Survival and toxicities outcome were evaluated by Kaplan-Meier method and according to NCI-CTC4.0.

Results: After dose adjustment, 59 patients (72.8%) received 500 mg daily of apatinib, 12 patients received 250mg, and 10 received 425mg daily. 44(54.3%) patients received apatinib alone and 37(45.7%) patients received apatinib combined with radiotherapy to primary tumor or metastatic sites. The median progression free survival (PFS) and overall survival (OS) was 5.9 (95% CI:4.6-7.2)and 10.8 (95% CI: 9.4-12.1) months. Compared with apatinib alone, the median PFS in patients with apatinib combined with radiotherapy were 4.2 and 7.4 months (P=0.01), respectively. The median OS in apatinib monotherapy and apatinib combined with radiotherapy were 8.9 and 11.3 months (P=0.47), respectively. The incidence of adverse events in grades 3-4 were 24.7%. The most common adverse events in this study were hypertension(40.7%), hand-foot syndrome(35.8%), fatigue (27.1%), proteinuria(25.9%), gastrointestinal toxicity (22.2%) , hemorrhage (12.3%) and mouth mucositis (11.1%).

Conclusion: Apatinib alone or combined with radiotherapy is efficacious in treating patients with advanced NSCLC after two or more lines of treatment failure, with acceptable toxic effects.

Author Disclosure: T. Li: None. Q. Wang: None. Y. Fan: None. L. Liang: None.

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TU_30_3615 - Apatinib Alone or Combined with Radiation Therapy As a Salvage Treatment in Advanced Non-Small Cell Lung Cancer Failed from Two or More Lines of Prior Chemotherapy or Molecular Targeted Therapy



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