Gynecological Cancer

PV QA 4 - Poster Viewing Q&A 4

TU_15_3465 - Concurrent Weekly Cisplatin Versus Triweekly Cisplatin Alone with Radiation Therapy in the Treatment of Local Advanced Cervical Cancer: A Meta-Analysis Result

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

Concurrent Weekly Cisplatin Versus Triweekly Cisplatin Alone with Radiation Therapy in the Treatment of Local Advanced Cervical Cancer: A Meta-Analysis Result
J. Zhu, Q. Chen, Q. C. Hu, K. Gu, and S. Ji; Department of Radiation Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, suzhou, China

Purpose/Objective(s): The meta-analysis was performed to distinguish better schedule between the regimens of weekly and triweekly single cisplatin concomitant chemoradiation in treatment of Local Advanced cervical carcinoma (LACC). We took compliance, recurrence, survival and acute adverse effect into consideration.

Materials/Methods: We conducted a systematic search for related studies in PubMed, Cochrane Library, EMBASE databases and Medline. fixed- or random-effects models were used in our study. The primary endpoints were compliance, overall survival and recurrence and acute adverse effect reported as odds ratios (ORs) and 95% confidence intervals (CIs).

Results: Six randomized trials and two retrospective studies that matched our recruitment criteria were selected into our study. We found that regimen of triweekly CDDP alone concurrent with RT has better compliance (OR, 0.45; 95% CI, 0.27-0.74; p = 0.002) for LACC. No significantly difference exists between the two arms in recurrence, survival and acute adverse effect (all P>0.05). However, triweekly CDDP regimen significantly reduced the incidence of local recurrence (OR, 1.93; 95% CI, 1.22, 3.05; p = 0.005) and weekly CDDP regimen has as a lower risk of leucopenia (OR, 0.30; 95% CI, 0.10,0.92; p = 0.03).

Conclusion: Triweekly single platinum chemotherapy plus concurrent RT significantly improved the compliance of patients with LACC, and reduced the local recurrence compared with weekly cisplatin regimen. But leucopenia occurred less relatively in weekly protocol. Therefore, triweekly single platinum combined with RT might be the optimal treatment regimen over weekly CDDP plus RT for LACC.

Author Disclosure: J. Zhu: None. Q. Chen: None. Q. Hu: None.

Send Email for Shengjun Ji


Assets

TU_15_3465 - Concurrent Weekly Cisplatin Versus Triweekly Cisplatin Alone with Radiation Therapy in the Treatment of Local Advanced Cervical Cancer: A Meta-Analysis Result



Attendees who have favorited this

Please enter your access key

The asset you are trying to access is locked. Please enter your access key to unlock.

Send Email for Concurrent Weekly Cisplatin Versus Triweekly Cisplatin Alone with Radiation Therapy in the Treatment of Local Advanced Cervical Cancer: A Meta-Analysis Result