Breast Cancer

PV QA 4 - Poster Viewing Q&A 4

TU_3_3351 - Local Recurrence Rates for Early Stage Breast Cancer Treated With Breast Conservation and Single Fraction IntraOperative Electron Radiation Therapy ( IOERT) at a Community Hospital

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

Local Recurrence Rates for Early Stage Breast Cancer Treated With Breast Conservation and Single Fraction IntraOperative Electron Radiation Therapy ( IOERT) at a Community Hospital
V. L. Williams, T. A. Bhandari, L. Chen, L. D. Wagman, M. Carpenter, J. K. Harness, R. Khanijou, M. Carandang, and R. B. Ash; St. Joseph Hospital, Orange, CA

Purpose/Objective(s): Patients with early stage breast cancer are offered adjuvant breast irradiation after lumpectomy to reduce the likelihood of recurrence . This is usually in the form of whole breast irradiation. However, large multi-institutional randomized data show that partial breast irradiation using single fraction intraoperative electron radiotherapy ( IOERT) may be safe and appropriate in a subset of patients with early stage disease. Our goal was to prospectively determine the local in-breast tumor recurrence ( IBTR) rate at a single community center using IOERT.

Materials/Methods: Patients with early stage breast cancer treated with breast conservation +/- SLNB and single fraction IOERT were enrolled prospectively in an in-house trial . Patient demographics , clinical/ pathologic staging , tumor histology , grade and receptor status were recorded. Patient eligibility included women age >/=40 yrs , primary tumor Results: 220 single fraction IOERT treatments were delivered between 2012-2017. Sixteen patients were subsequently excluded from this analysis because they received subsequent whole breast radiation based on adverse pathology. Of the remaining 203 treatment, 6 patients had bilateral IOERT ( total pts=197).The median follow up was 2.4 years. The median age was 65 yrs ( range 40-91). Pathology was as follows: 23% pure DCIS, 71% IDC +/- DCIS, 5% ILC , 1% mixed. 24% were stage 0, 72% were stage 1 and 5% stage 2 . 89% were low-intermediate grade while 11% were high grade. 90% were ER/PR positive. 11/197 patients recurred (5.6%). Of those, 7 developed ipsilateral in-breast tumor recurrence (6 local recurrences and 1 new primary). IBTR= 3.6%. Two developed systemic recurrence and two developed a new contralateral primary. Median time to recurrence was 2.7 years.

Conclusion: Our results show in -breast tumor recurrence rates for breast conservation with single fraction IOERT at 3.6%. These results are consistent with that of recently published randomized multicenter trials. Median follow up for this review is 2.4 years and further follow-up is required.

Author Disclosure: V.L. Williams: None. L. Chen: None. L.D. Wagman: None. M. Carpenter: None. R.B. Ash: None.

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