Breast Cancer

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TU_8_3393 - The Use of New Delineation Tool "MIRADA", Step-by-step Development and First Results of Its Use in Early Stage Breast Cancer Patients

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

The Use of New Delineation Tool “MIRADA”, Step-by-step Development and First Results of Its Use in Early Stage Breast Cancer Patients
H. Xu1,2, A. Arsene Henry1, M. Robillard1, M. Amessis1, and Y. Kirova1; 1Institut Curie, Paris, France, 2Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China

Purpose/Objective(s): To describe the practical procedure of implementation and optimization of delineation using “Mirada” software, as well as evaluation of the automatic segmentation for the daily practice of lymph nodes (LN) and OARs (organs at risk) in early stage breast cancer patients.

Materials/Methods: Forty patients’ CT scans in treatment position were selected and re-contoured according to the ESTRO guidelines. The atlas of dataset was then created for automatic delineation. Thirty patients with breast/chest wall and lymph nodes regions irradiated were recruited for evaluation. With the same treatment position, the CT scan images were acquired and then contoured by the MIRADA system automatically as well as by the radiation oncologist manually (as the reference). The Conformity Index (CI) was used to evaluate the concordance between both of them.

Results: The mean time for manual contour was 24.1±5.1 mins and 26.4±2.8 mins for the LN and the OARs respectively. All the volumes of interest were contoured using the software (including corrections) in 30 minutes, which reduced the time of delineation of target volumes and OAR by about 40%. Of the 30 cases evaluated, the mean CI of 5 principal OARs showed ≥ 0.8. While the automatic contour of LN was less satisfactory with mean CI of 0.43±0.1 (0.23-0.52).

Conclusion: For the breast cancer patients, the studied software permitted to save time for delineation with acceptable OAR contours. The improvement of LN regions contour is needed. More cases and further evaluation are needed for the system to realize its routine use.

Author Disclosure: H. Xu: None. A. Arsene Henry: None. M. Robillard: None. M. Amessis: None. Y. Kirova: None.

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