Breast Cancer

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TU_7_3388 - Breast Conservation Therapy Achieved Comparable Outcomes with Mastectomy in Patients with T1-2N0 Triple-Negative Breast Cancer: Analysis of 822 Patients in a Single Institution

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

Breast Conservation Therapy Achieved Comparable Outcomes with Mastectomy in Patients with T1-2N0 Triple-Negative Breast Cancer: Analysis of 822 Patients in a Single Institution
S. Wang1, Y. Tang2, H. Fang3, G. Sun4, H. Jing5, Y. W. Song3, J. Wang5, J. Jin5, Y. Liu6, H. Ren7, Z. Yu3, and Y. Li1; 1National Cancer Canter/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2National Cancer Center/Cancer Hospital and Institute, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 3State Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, 4Department of Radiation Oncology, National Cancer Canter/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 5National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 6Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 7Department of Radiation Oncology, National Cancer Center/Cancer Hospital and Institute, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China

Purpose/Objective(s): To compare the treatment outcomes of breast conserving surgery plus radiotherapy (BCS+RT) vs. mastectomy for patients with pT1-2N0 triple negative breast cancer (TNBC).

Materials/Methods: 822 patients with pT1-2N0 TNBC treated between 1999 and 2013 were analyzed. All patients underwent BCS+RT (n=158) or mastectomy without radiotherapy (n=664) with negative margins. All patients received adjuvant chemotherapy, mainly with anthrathycline- and/or taxane-based regimens. Survival and recurrence rates were calculated by using the Kaplan-Meier method and compared by log-rank test. Multivariate analysis was performed by Cox model.

Results: The median follow-up time was 69 months for all patients, 66 months for BCT+RT group and 70 months for mastectomy group.The median age was 48 years (range, 22 to 75 years). Compared with mastectomy group, BCT+RT group had more patients with age less than 50 years (74.1% vs. 51.8%, p < 0.001), and T1 tumors (79.1% vs. 48.5%, p<0.001). Other characteristics, including tumor grade, lymphovascular invasion and multiple tumors, were not significantly different between the two groups. The 5-year locoregional recurrence, disease-free, and overall survival rates of BCS+RT group vs. mastectomy group were 7.2% vs. 7.7%, 90.8% vs. 87.0%, and 98.8% vs. 94.5% respectively (p=0.481, p=0.119, and p=0.115). Multivariate analysis confirmed that the differences were not significant (p=0.682, p=0.208, and p=0.121, respectively). T2 tumors, age less than 50 years were independent unfavorable prognostic factors for LRR and DFS.

Conclusion: In pT1-2N0 TNBC, breast conserving surgery plus RT achieved comparable locoregional control, disease-free, and overall survival rates with mastectomy without RT, indicating breast conserving therapy is safe and mastectomy without RT is adequate.

Author Disclosure: S. Wang: None. G. Sun: None. H. Jing: Travel Expenses; Varian Corporate. Z. Yu: None.

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TU_7_3388 - Breast Conservation Therapy Achieved Comparable Outcomes with Mastectomy in Patients with T1-2N0 Triple-Negative Breast Cancer: Analysis of 822 Patients in a Single Institution



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