Breast Cancer

PV QA 4 - Poster Viewing Q&A 4

TU_2_3334 - Effects of Trastuzumab on Locoregional Recurrence in Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Patients Treated With Chemotherapy and Radiation Therapy

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

Effects of Trastuzumab on Locoregional Recurrence in Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Patients Treated With Chemotherapy and Radiation Therapy
S. H. Jeon1, K. H. Shin1, K. Kim2, and I. A. Kim3; 1Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea, Republic of (South), 2Department of Radiation Oncology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea, Republic of (South), 3Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea, Republic of (South)

Purpose/Objective(s): In the present study, the ability of adjuvant trastuzumab to reduce locoregional recurrence in patients with human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer receiving adjuvant chemotherapy and radiotherapy (RT) was investigated.

Materials/Methods: We retrospectively included 520 patients with HER2-overexpressing breast cancer who received surgery followed by adjuvant RT and cytotoxic chemotherapy from 2003 to 2011. Adjuvant trastuzumab was administered to 286 patients. Propensity score matching was conducted to compare trastuzumab-treated and non-treated cohorts.

Results: Median follow-up duration was 7.1 years (range, 1.1–14.1 years). Propensity score matching yielded 171 matched pairs of patients with no significantly different clinical factors. An improved 7-year locoregional control (LRC) rate was observed in the trastuzumab-treated cohort compared with the non-treated cohort (95.6% vs. 89.9%, p = 0.014). Based on multivariate analysis, hormone receptor negativity (hazard ratio [HR] = 5.348, p = 0.007), positive lymph node ratio > 0.25 (HR = 2.549, p = 0.040), and lack of adjuvant trastuzumab (HR = 3.401, p = 0.017) were identified as significant risk factors for poor LRC. Adjuvant trastuzumab significantly reduced the locoregional recurrence rate in patients with one or two risk factors (7-year LRC = 95.0% vs. 84.2%, p = 0.007); however, the benefit of adjuvant trastuzumab was non-significant in patients with no risk factors (7-year LRC = 95.8% vs. 97.9%, p = 0.75).

Conclusion: Adjuvant trastuzumab improved LRC in patients with HER2-overexpressing breast cancer receiving adjuvant RT and cytotoxic chemotherapy, especially in hormone receptor-negative, HER2-overexpressing, and high-positive lymph node ratio breast cancer.

Author Disclosure: S. Jeon: None. K. Kim: None.

Send Email for Seung Hyuck Jeon


Assets

TU_2_3334 - Effects of Trastuzumab on Locoregional Recurrence in Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Patients Treated With Chemotherapy and Radiation Therapy



Attendees who have favorited this

Please enter your access key

The asset you are trying to access is locked. Please enter your access key to unlock.

Send Email for Effects of Trastuzumab on Locoregional Recurrence in Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Patients Treated With Chemotherapy and Radiation Therapy