Gynecological Cancer

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TU_20_3516 - Benefits of Brachytherapy in Addition to External Beam Radiation in Early-Stage Endometrial Carcinoma: Analysis from a Multicenter Study

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

Benefits of Brachytherapy in Addition to External Beam Radiation in Early-Stage Endometrial Carcinoma: Analysis from a Multicenter Study
X. Hou1, W. Wang2, M. Shi3, L. Wei4, L. Zou5, T. Wang6, Z. Liu7, J. He8, X. Sun9, X. Li10, W. Zhong11, F. Zhao12, S. Li13, K. Hu14, and F. Zhang14; 1Peking Union Medical College Hospital, Beijing, China, 2Department of Radiation Oncology, Peking Union Medical College Hospital, Beijing, China, 3Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi 'an, China, 4Xijing Hospital, Xian 710032, China, 5The Second Affiliated Hospital of DaLian Medical University, DaLian, China, 6The second hospital of Jilin university, Jilin, China, 7Department of Radiation Oncology,The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China, 8Department of Radiation Oncology, General Hospital of Ningxia Medical University (Cancer hospital), Ningxia, China, Ningxia, China, 9Department of Radiation Oncology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, 10Department of Radiation Oncology, Peking University First Hospital, Beijing, China, 11Department of Radiation Oncology, Cancer Hospital Affiliated to Xinjiang Medical University, China, Xinjiang, China, 12Gansu Provincial Cancer Hospital, Lanzhou, China, 13Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing Cancer Hospital & Institute, Beijing, China, 14Department of radiation oncology, Peking Union Medical College Hospital. Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Purpose/Objective(s): To investigate the benefits of vaginal brachytherapy (VBT) in addition to external beam radiation (EBRT) on the basis of locoregional control improvements in early stage endometrial carcinoma.

Materials/Methods: Review of clinical data of patients with early-stage EC at 11 institutions in China between 2000 and 2016. Eligibility requirements included the primary hysterectomy/bilateral salpingo-oophorectomy and adjuvant radiotherapy, stage I and II disease (FIGO 2009 staging), and complete clinicopathologic and follow-up information. All patients were divided into low-, intermediate-, high-intermediate and high-risk groups according to ESMO-ESGO-ESTRO Consensus. Overall survival (OS), disease free survival (DFS), locoregional recurrence free survival (LRFS) and distant metastasis free survival (DMFS) rates were calculated using the Kaplan–Meier method, Cox proportional hazards regression model was used for multivariate analysis. Pearson chi-Square test was used to compare categorical variables between groups. Statistical analyses were performed with statistical software.

Results: A total of 909 early-stage patients were reviewed. The median follow-up time was 48 months (range 6–207 months). The median age was 57 years (range 23–86 years). Stage Ia/b disease represented 87.6% of the cohort, high-risk patients 20.8%. Patients received VBT alone (n = 426), EBRT alone (n = 117), EBRT+VBT (n = 366), and chemotherapy(n = 183). The 5-year OS, DFS, LRFS, and DMFS rates for all patients were 94%, 89.6%, 91.8%, and 91% respectively. Age>60, anemia before radiotherapy, and presence of lymphovascular invasion (LVSI) were found to be significant prognostic factors for OS (p = 0.016, 0.026, and 0.017). Myometrial invasion>1/2, anemia before radiotherapy, LVSI, and lower uterine segment involvement (LUSI) were found to be significant prognostic factors for DFS (p = 0.031, 0.011, 0.008, and 0.03). Subgroup analysis revealed that 62.8% of high-risk patients received EBRT+VBT, Patients received EBRT+VBT had significantly higher LRFS than patients received EBRT or VBT alone (89.7%, 86%, 76.7%, p = 0.002).

Conclusion: For high-risk early-stage EC, VBT in addition to EBRT maybe a better option with improvement of LRFS.

Author Disclosure: X. Hou: None. W. Wang: None. J. He: None. W. Zhong: None.

Xiaorong Hou, MD

Biography:
Name: Hou Xiaorong MD

Title: Assistant director physican, radiation oncology

Institute/Hospital: Peking Union Medical College Hospital

Education:
1995-2000 Peking University Health Science Center(PUHSC,Peking Medical University) ,Clinical Medicine, MB
2004-2007 Peking Union Medical College(PUMC, Peking Union Medical College, Tsinghua University), Oncology, MM
2010-2014 Peking Union Medical College(PUMC, Peking Union Medical College, Tsinghua University), Oncology, MD

Duty in other Institution:
Member of the clinical research group of Clinical Oncology Clinical Oncology Institute of thyroid
Member of esophageal cancer multi-center professional collaboration of Beijing Medical Association for radiation oncology
Member of intraoperative radiotherapy professional collaboration of Beijing Medical Association for radiation oncology

Awards:
Outstanding staff of PUMCH Award
Hundred-Talent Program of PUMCH
Outstanding paper award at the Chinese medicine eleventh times the National Radiation Oncology Conference
Outstanding paper award at the annual meeting of the Beijing Medical Association for radiation oncology
Best Innovation award at the annual meeting of the Beijing Medical Association for radiation oncology
Outstanding paper third award at the Chinese medicine fourteenth times the National Radiation Oncology Conference

Presentation(s):

Send Email for Xiaorong Hou


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