Lung Cancer

PV QA 4 - Poster Viewing Q&A 4

TU_31_3628 - A Prospective Study of MRI Assessment of Post-Radiation Changes Following Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

A Prospective Study of MRI Assessment of Post-Radiation Changes Following Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer
P. Munoz Schuffenegger1,2, S. Kandel3, Z. Allibhai4, A. J. Hope1,5, A. Bezjak1,2, A. Sun1,2, A. Simeonov1,2, J. Cho1,5, and M. E. Giuliani2,5; 1Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada, 2Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada, 3Joint Department of Medical Imaging, University of Toronto, Toronto, ON, Canada, 4Department of Radiation Oncology, Southlake Regional Cancer Centre, Newmarket, ON, Canada, 5Department of Radiation Oncology, Princess Margaret Cancer Centre-University of Toronto, Toronto, ON, Canada

Purpose/Objective(s): Follow up computed tomography (CT) scans after lung SBRT are difficult to interpret due to the presence of benign fibrosis that can difficult the detection of local recurrence. The objective of this study was to determine the feasibility of a novel thoracic magnetic resonance (MR) imaging protocol incorporating diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) imaging for the assessment of the treated lung parenchyma after SBRT.

Materials/Methods: On a prospective trial, MR images were acquired in 30 patients treated with SBRT (divided into three different cohorts according to the likelihood of local recurrence as per an expert panel). These images were assessed by an expert thoracic radiologist blinded to clinical data, who indicated local recurrence in a dichotomous fashion. Local recurrence was confirmed by biopsy or subsequent growth on follow up CT scans.

Results: 27 out of 30 patients were analyzable for local recurrence. MR imaging was conducted at a median of 27.3 months (range: 6.5 to 71 months) after SBRT. No side effects resulted from either MR imaging or contrast material administration. At a median follow up time of 45 months after treatment, three local recurrences had occurred. MR assessment diagnosed seven patients as having a local recurrence that was later confirmed in 3, and did not miss any of the confirmed local recurrences (table 1). Table 1. Recurrences according to MR assessment and comparison with clinical outcomes
Local recurrence (biopsy proven or consistent growth on CT scans)
Fibrosis Equivocal Suspicious
Yes No Yes No Yes No
MR Yes 0 1 1 2 2 2
No 0 8 0 6 0 5
When comparing apparent diffusion coefficient (ADC) values according to local recurrence, mean ADC value for the local recurrence-free group was 1770 x 10-3mm/s2 (range: 1038 to 3105 x 10-3mm/s2) and 981 x 10-3mm/s2 (range: 926.6 to 1065 x 10-3mm/s2) for the local recurrence group (p = 0.0014).

Conclusion: A 3.0 T MR imaging protocol incorporating DWI and DCE was feasible and confirmed the suspicion of local recurrence in patients with highly suspicious CT scans. MR imaging after SBRT could potentially allow for selecting patients for salvage treatment after local SBRT failure. Future work should be pursued to validate these findings.

Author Disclosure: P. Munoz Schuffenegger: None. S. Kandel: None. Z. Allibhai: None. A.J. Hope: Travel Expenses; Elekta, Inc. A. Bezjak: Past President; Canadian Association of Radiation Oncology (CARO). A. Sun: None. M.E. Giuliani: Honoraria; Elekta Inc. Travel Expenses; Elekta Inc. Chair, Education Committee; Canadian Association of Radiation Oncology.

Send Email for Pablo Munoz Schuffenegger


Assets

TU_31_3628 - A Prospective Study of MRI Assessment of Post-Radiation Changes Following Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer



Attendees who have favorited this

Please enter your access key

The asset you are trying to access is locked. Please enter your access key to unlock.

Send Email for A Prospective Study of MRI Assessment of Post-Radiation Changes Following Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer