PV QA 4 - Poster Viewing Q&A 4
TU_26_3579 - Correlation and Prognostic Values of Glucose Metabolism-Related Markers on Dual-Phase FDG PET/CT in Non-Small-Cell Lung Cancer
Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3
Correlation and Prognostic Values of Glucose Metabolism-Related Markers on Dual-Phase FDG PET/CT in Non-Small-Cell Lung Cancer
H. H. W. Chen1, J. J. Yan2, W. C. Su3, and N. T. Chiu4; 1Department of Radiation Oncology, National Cheng Kung University Hospital, Tainan, Taiwan, 2Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan, 3Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, 4National Cheng Kung University Hospital, Tainan, Taiwan
Purpose/Objective(s): To evaluate the relationship and prognostic values of glucose metabolism-related markers with temporal changes of 18F-FDG uptakes on dual-phase PET/CT in non-small-cell lung cancer.
Materials/Methods: We reviewed records of 151 patients with NSCLC who underwent pretreatment dual-phase 18F-FDG PET/CT scans acquired at 1 h and 2 h after injection. The SUV increment (SUVinc) of the primary lung tumor was the 2-h SUVmax minus the 1-h SUVmax. The retention index (RI) was calculated by dividing the increase in the 2-h SUVmax by the 1-h SUVmax. Immunohistochemical studies of glucose transporter 1 (GLUT-1) and hexokinase 2 (HK-2) on the paraffin-embedded pre-treatment tumor samples were performed. Correlations of metabolic markers with parameters extracted from dual-phase FDG-PET and patient survivals were analyzed.
Results: Expressions of GLUT-1 and HK-2 were positively correlated in lung tumors (P < 0.001). The SUVinc > 1 and RI > 15% had the best discriminative yield for disease-free survival (DFS). High-level expressions of both GLUT-1 and HK-2 were significantly correlated with SUVinc > 1 (all P < 0.01). However, neither GLUT-1 nor HK-2 expressions were significantly correlated with higher RI (P = 0.26 and 0.40, respectively). Both GLUT-1 and HK-2 were prognostic factors and associated with poor survival in NSCLC patients. Patients with co-overexpression of GLUT-1 and HK-2 had the worst DFS (P = 0.002).
Conclusion: High-level expressions of both GLUT-1 and HK-2 are significantly correlated with the increment of SUV but not RI on dual-phase FGD PET. GLUT-1 and HK-2 are prognostic markers in NSCLC.
Author Disclosure: H.H. Chen: None. J. Yan: None. W. Su: None. N. Chiu: None.