Lung Cancer

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TU_26_3579 - Correlation and Prognostic Values of Glucose Metabolism-Related Markers on Dual-Phase FDG PET/CT in Non-Small-Cell Lung Cancer

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

Correlation and Prognostic Values of Glucose Metabolism-Related Markers on Dual-Phase FDG PET/CT in Non-Small-Cell Lung Cancer
H. H. W. Chen1, J. J. Yan2, W. C. Su3, and N. T. Chiu4; 1Department of Radiation Oncology, National Cheng Kung University Hospital, Tainan, Taiwan, 2Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan, 3Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, 4National Cheng Kung University Hospital, Tainan, Taiwan

Purpose/Objective(s): To evaluate the relationship and prognostic values of glucose metabolism-related markers with temporal changes of 18F-FDG uptakes on dual-phase PET/CT in non-small-cell lung cancer.

Materials/Methods: We reviewed records of 151 patients with NSCLC who underwent pretreatment dual-phase 18F-FDG PET/CT scans acquired at 1 h and 2 h after injection. The SUV increment (SUVinc) of the primary lung tumor was the 2-h SUVmax minus the 1-h SUVmax. The retention index (RI) was calculated by dividing the increase in the 2-h SUVmax by the 1-h SUVmax. Immunohistochemical studies of glucose transporter 1 (GLUT-1) and hexokinase 2 (HK-2) on the paraffin-embedded pre-treatment tumor samples were performed. Correlations of metabolic markers with parameters extracted from dual-phase FDG-PET and patient survivals were analyzed.

Results: Expressions of GLUT-1 and HK-2 were positively correlated in lung tumors (P < 0.001). The SUVinc > 1 and RI > 15% had the best discriminative yield for disease-free survival (DFS). High-level expressions of both GLUT-1 and HK-2 were significantly correlated with SUVinc > 1 (all P < 0.01). However, neither GLUT-1 nor HK-2 expressions were significantly correlated with higher RI (P = 0.26 and 0.40, respectively). Both GLUT-1 and HK-2 were prognostic factors and associated with poor survival in NSCLC patients. Patients with co-overexpression of GLUT-1 and HK-2 had the worst DFS (P = 0.002).

Conclusion: High-level expressions of both GLUT-1 and HK-2 are significantly correlated with the increment of SUV but not RI on dual-phase FGD PET. GLUT-1 and HK-2 are prognostic markers in NSCLC.

Author Disclosure: H.H. Chen: None. J. Yan: None. W. Su: None. N. Chiu: None.

Helen Chen, MD, PhD

Taiwan National Cheng Kung University Hospital

Biography:
Dr. Helen H.W. Chen is an M.D. Ph.D, and a Professor in the Department of Radiology at College of Medicine, National Cheng Kung University, Tainan, Taiwan. She has been working as a radiation oncologist at National Cheng Kung University Hospital for more than 25 years. She maintains very active research activities and has published more than 90 research articles in peer-reviewed journals. She collaborates closely with several clinical oncologists and basic scientists on projects involved with cancer research in breast cancer, lung cancer and gynecological cancers. Her expertise in translational radiation oncology is identifying surrogate biomarkers to predict treatment response and prognosis of cancer. Her research interests focus on development of effective strategies to overcome drug and radiation resistance in cancer therapy through molecular mechanistic studies using molecular, biochemical, and pharmacological tools.

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