Lung Cancer

PV QA 4 - Poster Viewing Q&A 4

TU_30_3620 - Comparison of Single- and Five-Fraction Regimens of Stereotactic Body Radiation Therapy for Peripheral Early-Stage Non-Small Cell Lung Cancer: A Two-Institution Propensity Matched Analysis

Tuesday, October 23
2:45 PM - 4:15 PM
Location: Innovation Hub, Exhibit Hall 3

Comparison of Single- and Five-Fraction Regimens of Stereotactic Body Radiation Therapy for Peripheral Early-Stage Non-Small Cell Lung Cancer: A Two-Institution Propensity Matched Analysis
S. J. Ma1, M. A. Cummings2, G. M. Hermann3, L. Serra1, Y. A. Syed1, Y. Chen4, M. T. Milano2, J. A. Gomez Suescun3, D. P. Singh5, and A. K. Singh3; 1Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, 2University of Rochester Medical Center, Rochester, NY, 3Roswell Park Cancer Institute, Buffalo, NY, 4Wilmot Cancer Institute, University of Rochester, Rochester, NY, 5Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY

Purpose/Objective(s): To assess the outcome of early-stage non-small cell lung cancer (NSCLC) treated with single- versus five-fraction stereotactic body radiation therapy (SBRT) at two institutions

Materials/Methods: In our study, peripheral early-stage NSCLC cases treated with either a median dose of 30 Gy (IQR 30-30, BED 120-120) in a single fraction or a median dose of 50 Gy (IQR 50-50, BED 100-100) in five fractions were included. Data were retrospectively collected in an institutional review board-approved database. Statistical software was used for statistical analysis.

Results: Of total 163 lesions treated between 2007 and 2015, 65 received single-fraction SBRT and 98 received five-fraction SBRT. The five-fraction SBRT cohort had significantly smaller tumors (p<0.001), and a larger tumor size was a prognostic factor for worse survival (HR 1.28, P=0.029). No grade 3 or higher toxicity was observed in the single-fraction SBRT cohort, while a single grade 3 symptomatic pneumonitis was seen in the five-fraction SBRT cohort. Propensity score matching resulted in the cohort of 90 patients with median follow-up of 26.5 months (IQR 16.2-34.7) for the single-fraction cohort and 34.0 months (IQR 21.0-48.0) for the five-fraction cohort (p=0.054). There were no statistically significant differences between these two regimens in overall survival (p=0.19), progression-free survival (p=0.89), local failure (p=0.38), and nodal or distant failure (p=0.76) at 2 years.

Conclusion: The single- and five-fraction SBRT cohorts had comparable outcomes and were well tolerated. Increasing tumor size was associated with worse survival. Both regimens are reasonable treatment options for early-stage peripheral NSCLC.

Author Disclosure: S. Ma: None. M.A. Cummings: None. G.M. Hermann: None. L. Serra: None. Y.A. Syed: None. Y. Chen: None. M.T. Milano: Honoraria; UpToDate. J. Gomez Suescun: None. D.P. Singh: None.

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TU_30_3620 - Comparison of Single- and Five-Fraction Regimens of Stereotactic Body Radiation Therapy for Peripheral Early-Stage Non-Small Cell Lung Cancer: A Two-Institution Propensity Matched Analysis



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