Radiation and Cancer Biology
EDU 25 (Live SA-CME) - Translational Genomics to Advance Precision Radiation Oncology
1:00 PM - 2:30 PM
Location: Room 006
Session Type: Educational
1.50 AMA PRA Category 1 Credits™
1.50 CAMPEP Credits
1.50 MDCB Credits
To receive Live SA-CME credit, you must add this session to your registration for an additional fee. For Live SA-CME credit you must present your ticket at the door and complete the online assessment. Space is limited, so please register early. Please note that events and fees are subject to change.
For CME credit you DO NOT NEED TO REGISTER FOR THIS SESSION.
Large-scale genomics studies are transforming our understanding of tumor biology; however, despite a dramatic increase in available data, translating genomic findings to clinical practice remains a significant challenge. This session will focus on current efforts to leverage genomic data to advance clinical radiation oncology. Presentations will describe preclinical systems used in genomic analyses and will explain the biological and technical underpinnings of common genomic assays. All speakers are active translational investigators and will highlight different genomic platforms in current use, including DNA-based mutational and copy-number analyses, RNA-based gene expression analyses, and metabolic/proteomic approaches. We will examine several representative biomarkers in detail to highlight the path from biomarker discovery to clinical implementation. Finally, we will describe the challenges that exist when attempting to validate tumor genomic features as prognostic and/or predictive biomarkers, and we will highlight what we see as opportunities for on-going investigations that are unique to radiation oncology.
- Describe the different types of genomic analyses that are frequently used to characterize tumors and define genomic subtypes.
- Explain the steps required to validate a specific genomic association as a prognostic and/or predictive biomarker.
- Determine which available genomics-based assays may be most relevant to their clinical practice.
1:20 PM - 1:40 PM
Mutation-based biomarkers of clinical radiation response
Speaker: – Memorial Sloan Kettering Cancer Center
1:40 PM - 2:00 PM
Gene expression-based biomarkers of clinical radiation response
Speaker: – University of Michigan
2:00 PM - 2:20 PM
Using genomics to inform rationale combination therapies