Radiation and Cancer Biology

Panel 06 - The Translational Potential of Liquid Biopsies for Predicting Radiation Response

10/22/2018
10:45 AM - 12:15 PM
Location: Room 304

Session Type: Panel
1.50 AMA PRA Category 1 Credits™
1.50 CAMPEP Credits
1.50 MDCB Credits

Human cancer exhibits extensive genomic and transcriptomic heterogeneity. Defining and understanding this heterogeneity to improve treatment efficacy is challenging. Traditionally such experimental approaches have depended on invasive tumor biopsies to obtain tumor tissue for genomic analysis. However, less-invasive liquid biopsies utilizing high-resolution genomic and gene expression data from state-of-the-art sequencing methodologies are now becoming common, these methods are more convenient that invasive biopsies and allow repeat sampling. For example, tumor cells and circulating tumor DNA is continually released into the blood and these can be detected and monitored as predictors of treatment response. Combining such molecular approaches allows a genomic fingerprint to be obtained to guide clinical practice. This session will summarize the pre-clinical and clinical research investigating molecular heterogeneity of cancer cells at the whole-cell, genomic and transcriptomic levels, and describe how tumor heterogeneity affects tumor aggressiveness and metastasis, with the aim of providing experimental approaches to improve patient care.

Learning Objectives:

Presentations:

George Wilson, PhD

William Beaumont Hospital

Disclosure:
No relationships to disclose.

Presentation(s):

Send Email for George Wilson


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