Radiation and Cancer Biology

Panel 16 - Exploiting the DNA Damage Response to Improve the Response to Radiation Therapy

10/24/2018
11:00 AM - 12:30 PM
Location: Room 304

Session Type: Panel
1.50 AMA PRA Category 1 Credits™
1.50 CAMPEP Credits
1.50 MDCB Credits

This session was proudly submitted as a joint session with the Radiation Research Society (RSS). Over the past two decades, tremendous advances have been made in understanding the molecular mechanisms regulating the response of cells to ionizing radiation. For, example radiation causes DNA damage that activate kinases, such as DNA-PK and ATM, that orchestrate the repair of DNA damage and activation of the p53 tumor suppressor protein. Drugs targeting these kinases or other regulators of p53 are now entering clinical trials with radiation therapy. This session will provide an overview of the DNA damage response pathway, highlight pre-clinical studies demonstrating synergy between radiation and drugs that modify the DNA damage response and discuss on-going or planned clinical trials testing this combination in the clinic.

Learning Objectives:

Presentations:

Henning Willers, MD

Disclosure:
Employment
Boston Medical Center: Attending physician: Employee; Massachusetts General Hospital: Associate Radiation Oncologist: Employee

Compensation
Aid for Cancer Research: Research Grants; Medscape: Honoraria; NCI: Research Grants

Leadership
Radiation Research Society: Elected Councilor

Presentation(s):

Send Email for Henning Willers

Julie Schwarz, MD, PhD

Washington University School of Medicine

Disclosure:
Employment
Washington University: Assistant Professor: Employee, Associate Professor: Employee

Compensation
AACR: Travel Expenses; Burroughs Wellcome Fund: Research Grants; Mallinckrodt Foundation: Research Grants; NIH: Research Grants; RRS: Travel Expenses

Presentation(s):

Send Email for Julie Schwarz


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