Brian Shuch

Yale School of Medicine

I joined the faculty at Yale in August 2013 as a urologic surgeon after completing urology residency at UCLA and an oncology research fellowship at the National Cancer Institute (NCI). I have specific interest in the genetics of urologic cancers and have helped describe the clinical manifestations of several kidney cancer syndromes while at the NCI as well as establish kidney genetic testing guidelines. I served on the Cancer Genome Atlas (TCGA) kidney cancer working groups, the NCI PDQ Cancer Genetics Board, and the NCCN Kidney Cancer Guidelines Panel. My clinical responsibilities focus on kidney cancer and I run the Yale Genitourinary Cancer Genetics clinic and have a clinical protocol for surveillance of the small renal mass. I perform open, laparoscopic, robotic, and percutaneous kidney surgeries and am an active investigator several adjuvant and neoadjuvant protocols. I am active in the SWOG GU Cancer group and the SUO Clinical Trial Consortium. I serve as the Director of the Yale Genitourinary Cancer Biospecimen Repository and run a translational research laboratory. My current translational research involves evaluation of renal tumor heterogeneity, using bioinformatics to guide clinical treatment, the molecular mechanisms associated with sarcomatoid transformation, and predictive markers of response to MET inhibitors in papillary kidney cancer.


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