John C. Lieske

Mayo Clinic

John C. Lieske, M.D. is currently Professor of Medicine at the Mayo Clinic College of Medicine, and the Director of the Renal Function Laboratory in the Department of Laboratory Medicine and Pathology. Dr. Lieske is also Principal Investigator for the Mayo Clinic O’Brien Urology Research Center, Assistant Director for the Rare Kidney Stone Consortium (Director of the Dent Disease component), and Principal Investigator for the Mayo NIH Nephrology Training Grant. He has a longstanding interest in urinary proteomics and nephrolithiasis, including NIH-funded projects to investigate inhibitors of crystal aggregation, growth, and adhesion to tubular cells; epidemiology of nephrolithiasis; genetics of nephrolithiasis; and mechanisms of enteric hyperoxaluria. As director of the Renal Function Lab, Dr. Lieske has also developed expertise regarding renal markers of renal disease including tandem-MS based assays for urinary biomarkers and validation of newer markers of injury and kidney function (e.g., cystatin C, NGAL). Dr. Lieske has previously conducted clinical trials regarding the role of diet and probiotics in patients with and without enteric hyperoxaluria. He has also studied the epidemiology of enteric hyperoxaluria and kidney disease after bariatric surgery and the pathogenesis of kidney stone precursor lesions.


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