In the minds of many patients, root canal therapy is associated with pain. This mindset can often lead to the expectation for post-operative analgesic medications or, worse still, pursuit of dental extraction. As endodontists, we generate heuristics for "case types" that are likely to result in significant post-operative pain such as lower molars with severe pulpitis, retreatments, and teeth that are exquisitely percussion tender. This lecture is intended to look at an option that may offer us the ability to meaningfully reduce pain across all case types.