Sahng Gyoon Kim, D.D.S., M.S.
Director, Postgraduate Program/Associate Professor of Dental Medicine at CUMC
Division of Endodontics, College of Dental Medicine, Columbia University
Columbia University
Disclosures: Snoasis: Grant/Research Support
Vanessa Chrepa, D.D.S., M.S.
Assistant Professor
University of Texas Health Science Center at San Antonio
The goal of regenerative endodontic therapy is to restore the functional integrity of the pulp-dentin complex by applying a combination of biomaterial scaffolds, cells, and biological molecules. As one of the key components in tissue engineering, biomaterial scaffolds provide the structural framework for the regeneration of the pulp-dentin complex. New biological scaffolds functionalized with biological cues such as growth factors and dentin matrix molecules have been designed and investigated to direct a myriad of cellular activities toward pulp regeneration. This lecture will systematically review the properties and biological performance of biomaterial scaffolds utilized in clinical trials and animal studies. Additionally, the histological outcomes of regenerative endodontic treatment in animal models using different scaffolds will be presented based on the findings from the author’s laboratory. The potential application of biological scaffolds for clinical regenerative endodontic therapy will also be discussed for practitioners.