The term cryotherapy is derived from the Greek word cryos, meaning “cold”. The application of cold to human tissue has been shown to decrease nerve conduction velocity, reduce hemorrhage and edema, along with inflammation. Although the use of cyrotherapy has been common practice in medicine and other fields within dentistry, to date, it has not been applied in vital pulp therapy (VPT). The integration of cryotherapy on pulpal tissue exposed or indirectly exposed, due to a carious lesion excavation, in conjunction with EDTA, bioceramics and restorative materials has shown to reduce postoperative pain. This presentation will cover clinical case selection, treatment and prognosis, through the understanding of proper diagnosis, materials and biological considerations, when performing vital pulp cryotherapy treatment.