It has been long recognized that the key to endodontic success is largely determined by how well the root canal system is disinfected. To render the canal bacteria-free is challenging. Mechanical debridement alone is limited in reaching all the root canal spaces. Recent endeavors on advancing regenerative endodontics further underscores the importance of effective root canal disinfection. Thus, strategies for root canal disinfection should be directed to use more effective irrigation activation techniques that may maximize root canal disinfection.
In this presentation, we will overview, analyze and discuss two areas:
i) Recent endeavor on improving the efficacy of root canal disinfection including the use of various newly devices, equipment and anti-microbial protocols in reducing the antimicrobial loads without further damage to the progenitor cells.
ii) Utilization of large animal models such as mini-swine to study cell-based pulp regeneration and testing disinfection protocols.
Whether regenerative procedures are suited for heavily infected root canal with periapical lesions will be analyzed and discussed.