Endodontists should play a pivotal role in the diagnosis and the treatment planning of comprehensive cases. The negative impact of occlusal trauma on the periodontium has been thoroughly investigated. However, little attention has been given to the effects of occlusal trauma on the integrity of the human dental pulp and the surrounding hard tissue structures. This lecture will discuss the less known consequences of occlusal trauma such as accelerated pulpal tissue degeneration and the role of occlusal trauma on external root resorption. The implications of occlusal forces on periapical healing and the survivability of endodontically treated teeth will also be addressed.