Neurologic injury as an outcome of endodontic treatment can have devastating consequences for both the patient and the endodontist. Mishaps that occur during the therapeutic stages of endodontic therapy can result in neurologic damage with an unpredictable course and an uncertain prognosis. Dr. Gluskin will discuss the evidence and best practices regarding neurologic injury as a result of endodontic care. He will review the data for prognosis and how to determine treatment and intervention strategies as a result of the chemical harm from overfill. Dr. Gregg will discuss orofacial neuroanatomy, the spectrum of trigeminal nerve injuries, differential diagnosis of post-trauma, neuropathic pain sequelae (peripheral and central), and especially surgical, non-surgical and rehabilitative interventions with outcome expectations.