The presentation includes a selection of cases encountered in my practice. The presentation highlights the role played by the dental professional in the overall health of the patient. The underlying disease condition was discovered in each of these cases following a diagnosis of lesions of the oral cavity and jawbones. A spectrum of unique conditions presented will include hypersensitivity/autoimmune, gastrointestinal, hematological, bone, nerve and psychological entities. The presentation will consist of documented high-resolution clinical, imaging and histopathological images as applicable.