Muaz Aijazi, MD1, Ashish Ahuja, MD1, George W. Williams, MD2
1University of Pittsburgh Medical Center Mercy, Pittsburgh, PA; 2University of Texas Health Science Center, Houston, TX
Introduction: Heparin-induced thrombocytopenia (HIT) is a rare, but life-threatening, complication seen in approximately 5% of those exposure to heparin for more than 4 days. It is currently believed that the female sex, surgical patients, and those greater than age 40 are at increased risk for developing HIT.1 Here, we explore the possibility of increased risk of HIT in patients who are known to have inflammatory bowel disease.
Methods: We used the National Inpatient Sample (NIS) from 2010 to 2012 to identify 14,121 patients with an ICD-9CM code for HIT. Patients with diagnosis codes for Crohn’s disease or ulcerative colitis were classified as having IBD. Outcomes in patients with IBD were compared to those without immune mediated conditions using chi-square and student’s t-test where appropriate.
Results: Of the 14,121 HIT patients identified, 103 had a pre-existing diagnosis of Crohn’s disease and 56 had pre-existing ulcerative colitis. Having a prior diagnosis of Crohn’s disease corresponded to an OR of 1.17 (p-value 0.115, 95% CI 0.96, 1.42) for subsequently developing HIT. Ulcerative colitis conferred an OR of 1.12 for developing HIT (p= 0.4, CI 0.86, 1.46). A statistically significant change was not demonstrated for either disease.
Discussion: Our study shows that having a diagnosis of IBD does not significantly increase risk of developing HIT. This is interesting considering IBD is considered as gastrointestinal immune disorders. Also of note, while they themselves are technically not considered autoimmune – it has been demonstrated in the literature that immune mediated diseases were significantly more frequent in patients with IBD.2 Prospective research will be required to further elucidate a relationship between IBD and HIT.
Citation: Muaz Aijazi, MD; Ashish Ahuja, MD; George W. Williams, MD. P2275 - DOES INFLAMMATORY BOWEL DISEASE PREDISPOSE PATIENTS TO AN INCREASED RISK OF HEPARIN-INDUCED THROMBOCYTOPENIA?. Program No. P2275. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.