Award: Presidential Poster Award
Komal Lakhani, MD, Laura Durbin, Manasi Agrawal, MD, Richa Bhardwaj, MBBS, Arun Swaminath, MD
Lenox Hill Hospital, New York, NY
Introduction: Fatigue is a subjective and underdiagnosed symptom prevalent in nearly half of all inflammatory bowel diseases (IBD) patients and can be highly debilitating. It is more common in Crohn’s disease (CD) than in ulcerative colitis (UC) and is associated with disease activity. The purpose of our study was to determine patient and disease variables associated with fatigue in a tertiary referral center in New York City.
Methods: IBD patients were asked to complete the validated 8-item PROMIS Fatigue Short Form 8a, with a T-score of ≥50 and < 50 indicating high and low levels of fatigue over the previous 7 days. Variables such as age, sex, IBD type, body mass index (BMI), and disease remission status (clinical, endoscopic, and histologic) were determined on chart review at the same time.
Results: Of 187 IBD patients included in the study, 113 had CD (Table 1). In our sample, 48.7% of all IBD patients reported high fatigue. Fatigue was not associated with age, sex, BMI, or IBD type (Table 2). In multivariable models, adjusted for age and sex, clinical remission (OR 0.42, 95% CI 0.23-0.76) and endoscopic remission (OR 0.44, 95% CI 0.22-0.88), but not histologic remission (OR 0.43, 95% CI 0.18-1.01), were inversely associated with fatigue.
Discussion: Fatigue is a common symptom in IBD patients and is inversely associated with clinical and endoscopic, but not histologic, remission in this single-center cross-sectional study. These findings corroborate the role of disease activity in fatigue in IBD and emphasize the impact of achieving clinical and endoscopic remission.
Citation: Komal Lakhani, MD, Laura Durbin, Manasi Agrawal, MD, Richa Bhardwaj, MBBS, Arun Swaminath, MD. P0511 - FATIGUE IS INVERSELY ASSOCIATED WITH ENDOSCOPIC BUT NOT HISTOLOGIC REMISSION IN IBD PATIENTS. Program No. P0511. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.