Farina Hanif, MBBS, FCPS (Gastro), Nasir Mehmood, MBBS, Syed Mudassir Laeeq, MBBS, FCPS (Gastro), Nasir Hassan Luck, MBBS, FCPS (Med), FCPS (Gastro), Shoaib Ahmed Khan, MBBS, Sandeep Kumar, MBBS
Sindh Institute of Urology and Transplantation, Karachi, Sindh, Pakistan
Hepatitis B vaccine is extremely potent, however, 5% of healthy population and around 50% of hemodialysis patients do not respond to its intramuscular administration. We aim to determine the effectiveness of intradermal Hepatitis B vaccine in both dialysis and general population, who previously were non responder to its intramuscular form.
All participants were enrolled from January 2010 to 2019, received 5 doses of 10 µgm Hepatitis B vaccine via intradermal route every 2 weeks. Hepatitis Bs antibody (HBsAb) titer were checked 6 weeks after the last dose. Participants were consider as responder if HBsAb titer was more than 10 IU/L and good responder if more than 100 IU/L.
In 95 participants, majority were female (51.6%) with mean age of 39.0±13.5 years. Forty nine participants (51.6 %) were on maintenance hemodialysis. The risk factors for hepatitis B included intramuscular/intravenous injection in 85 (89.5 %), blood transfusion in 56 (58.9 %) and surgical procedures in 45 (47.4 %) subjects. The mean HBsAb titer level was 263.5±350.1IU/L. Overall, 72 (75.8%) participants responded to vaccination, 42 (44.2 %) of which achieved good response. Similar vaccination response was noted between hemodialysis and general population i.e.,75.5% and 76.1%,respectively.(p=1.00) Although a good response was observed more in hemodialysis patients (49%) than in general population (39.1%) however, it was not statistically significant. (p= 0.41)
Intradermal hepatitis vaccination showed good response in those previously unresponsive to intramuscular route. Study participants on maintenance hemodialysis showed a similar response rate as the general population.
Citation: Farina Hanif, MBBS, FCPS (Gastro), Nasir Mehmood, MBBS, Syed Mudassir Laeeq, MBBS, FCPS (Gastro), Nasir Hassan Luck, MBBS, FCPS (Med), FCPS (Gastro), Shoaib Ahmed Khan, MBBS, Sandeep Kumar, MBBS. P1518 - COMPARABLE RESPONSE OF INTRADERMAL HEPATITIS B VACCINATION IN DIALYSIS AND GENERAL POPULATION NON REPSONDER TO INTRA-MUSCULAR ROUTE. Program No. P1518. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.