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P1017 - PDGF-BB and Receptor Augment Epithelial-Mesenchymal Transition in Colorectal Cancers

Monday, October 28

10:30 AM - 4:15 PM

Location: Exhibit Halls 3 and 4 (Street Level)

Presenting Author(s)

BC

Byungha Cho

Cheongju, Ch'ungch'ong-bukto, Republic of Korea

Byungha Cho¹, Seung-Myoung Son¹, Ki Bae Kim¹, Eun Jeoung Lee¹, Sang-Jeon Lee¹, Seon Mee Park, MD², Jongwook Choi¹, Hyeonwoo Kwon, MD², Seongmin Kim, MD², Jun Su Lee, MD¹

¹Chungbuk National University Hospital, Cheongju, Ch'ungch'ong-bukto, Republic of Korea; ²Chungbuk National University Hospital, Cheongju-si, Ch'ungch'ong-bukto, Republic of Korea

Introduction: Platelet-derived growth factor (PDGF) and its receptor (PDGFR) signaling are key regulators of the tumor microenvironment and they contribute to tumor progression. We evaluated the correlation of PDGF-BB and PDGFR expression with the activation of epithelial-mesenchymal transition (EMT) and cancer-associated fibroblasts (CAFs) in colorectal cancer (CRC) tissues.

Methods: We evaluated PDGF-BB and PDGFR expression, EMT activity (E-cadherin loss and S100A4 gain in tumor cells), and CAFs (aSMA and S100A4 in stromal cells) via immunohistochemistry analysis of 270 CRC tissues. The expression levels of PDGF-BB/PDGFR, EMT, and CAFs were analyzed in the relation to pathological parameters and disease-free and overall survival times.

Results: PDGF-BB in tumor cells and PDGFR in both tumor and stromal cells were expressed. Spindle-shaped stromal cells exhibited expression of both PDGFR and aSMA. PDGFR expression was related to lymphovascular invasion, lymph node metastasis, AJCC stages, and high number of tumor buds. PDGF-BB was weakly related to lymph node metastasis and perineural invasion. PDGFR expression was related with E-cadherin loss and stromal expression of S100A4 and aSMA. PDGF-BB or PDGFR expression was not associated with the disease-free or overall survival time of CRC patients.

Discussion: PDGFR expression was related to the activity of CAFs and the EMT process. PDGFR have a crucial role in tumor progression and could be a main target for microenvironment control in CRC treatment.

Disclosures:

Byungha Cho indicated no relevant financial relationships.

Seung-Myoung Son indicated no relevant financial relationships.

Ki Bae Kim indicated no relevant financial relationships.

Eun Jeoung Lee indicated no relevant financial relationships.

Sang-Jeon Lee indicated no relevant financial relationships.

Seon Mee Park indicated no relevant financial relationships.

Jongwook Choi indicated no relevant financial relationships.

Hyeonwoo Kwon indicated no relevant financial relationships.

Seongmin Kim indicated no relevant financial relationships.

Jun Su Lee indicated no relevant financial relationships.

Citation: Byungha Cho; Seung-Myoung Son; Ki Bae Kim; Eun Jeoung Lee; Sang-Jeon Lee; Seon Mee Park, MD; Jongwook Choi; Hyeonwoo Kwon, MD; Seongmin Kim, MD; Jun Su Lee, MD. P1017 - PDGF-BB AND RECEPTOR AUGMENT EPITHELIAL-MESENCHYMAL TRANSITION IN COLORECTAL CANCERS. Program No. P1017. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.