Firas Baidoun, MD, Muhammad Talal Sarmini, MD, Yasser Alkhadra, MD, George Khoudari, MD, Bo Shen, MD, FACG
Cleveland Clinic Foundation, Cleveland, OH
Introduction: Inflammatory bowel disease (IBD) with its two major forms, ulcerative colitis (UC) and Crohn disease (CD), has an increasing incidence rate worldwide. Vitamin D deficiency is a common disorder and it has been more prevalent in the last two decades. Multiple studies have shown a link between vitamin D level and IBD severity raising the question of vitamin D deficiency role as a risk factor for IBD. The goal of this study is to investigate the association between vitamin D deficiency and IBD using a large inpatient data base.
Methods: By using the data from the National Inpatient Sample (NIS) database between 2002 and 2014, we identified the patients with vitamin D deficiency and IBD diagnosis using the International Classification of Diseases 9th version codes (ICD-9). The control group was the patients without vitamin D deficiency using the ICD-9 codes. We did multivariate logistic regression analysis to calculate the association between vitamin Ddeficiency and IBD.
Results: The study had total 101,137,145 patients. The vitamin D deficiency group had 339,418 patients (0.34%). We noticed that patients with vitamin D deficiency were older with mean age (63 vs 48), had more African American patients (17% vs 14%) and more female patients (67% vs 58%) (P< 0.001 for all). The vitamin D deficiency group had more patients with obesity (16% vs 7%) and more tobacco use (11% vs 10%) (P< 0.001 for all) (Fig 1). Using univariate analysis, we found patients with vitamin D deficiency had higher rate of IBD compared with patients without vitamin D deficiency (Odds Ratio [OR], 2.539, 95% confidence interval [CI], 2.474 - 2.605, P < 0.001), then we used multivariate logistic regression analysis, and after adjusting for potential cofounding factors, patients with vitamin D deficiency had a statistically significant higher rate of IBD (Odds Ratio [OR], 2.35, 95% confidence interval [CI], 2.285 - 2.417, P < 0.001) compared with patients without vitamin D deficiency(Fig 2).
Discussion: Based on our study we found that patients with vitamin D deficiency have two times higher risk of having IBD compared to patients without vitamin D deficiency. This raise the importance of screening for vitamin D deficiency in IBD patients. Further studies are needed to assess the role of vitamin D supplement in IBD course and outcome.
Citation: Firas Baidoun, MD, Muhammad Talal Sarmini, MD, Yasser Alkhadra, MD, George Khoudari, MD, Bo Shen, MD, FACG. P1414 - ASSOCIATION BETWEEN VITAMIN D DEFICIENCY AND INFLAMMATORY BOWEL DISEASE (IBD). Program No. P1414. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.