Firas Baidoun, MD, Muhammad Talal Sarmini, MD, Yasser Alkhadra, MD, George Khoudari, MD, Arthur J. McCullough, MD
Cleveland Clinic Foundation, Cleveland, OH
Nonalcoholic fatty liver disease (NAFLD) is the leading cause for chronic liver disease in western countries and a major leading cause of morbidity and mortality in the United States. Vitamin D deficiency has been associated with obesity, diabetes mellitus and metabolic syndrome, all of which are risk factors for NAFLD. The goal of this study was to investigate the association between vitamin D deficiency and NAFLD using a large inpatient date base.
By using the data from the National Inpatient Sample (NIS) database between 2002 and 2014, we identified the patients with the diagnoses of vitamin D deficiency and NAFLD using the International Classification of
Diseases 9th version codes (ICD-9). The control group was the patients without vitamin D deficiency using the ICD-9 codes. We performed multivariate logistic regression analysis to calculate the association between vitamin D deficiency and NAFLD.
The study had total 101,137,145 patients. The vitamin D deficiency group had 339,418 patients (0.34%). We noticed that patients with vitamin D deficiency were older (63 vs 48), and more likely to be African American (17% vs 14%) and female (67% vs 58%) (P< 0.001 for all). The vitamin D deficiency group also had more patients with obesity (16% vs 7%), hyperlipidemia (34% vs 13%), hypertension (59% vs 36%) hypothyroidism (19% vs 8%) uncomplicated diabetes mellitus (21% vs 14%) and chronic diabetes mellitus with complications (8% vs 3%) (P < 0.001 for all). Using Multivariate logistic regression, and after adjusting for potential cofounding factors, patients with vitamin D deficiency had a statistically significant higher rate of NAFLD (Odds Ratio [OR], 2.946, 95% confidence interval [CI], 2.859 -3.036, P < 0.001) compared with patients without vitamin D deficiency.
Based on our study we found that patients with vitamin D deficiency have three times higher risk of having NAFLD compared to patients without vitamin D deficiency. These data emphasize the importance of screening for vitamin D deficiency in NAFLD patients. Further studies are needed to assess the role of vitamin D supplement in NAFLD progression.
Citation: Firas Baidoun, MD, Muhammad Talal Sarmini, MD, Yasser Alkhadra, MD, George Khoudari, MD, Arthur J. McCullough, MD. P1558 - ASSOCIATION BETWEEN VITAMIN D DEFICIENCY AND NONALCOHOLIC FATTY LIVER DISEASE (NAFLD). Program No. P1558. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.