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P0937 - Hepatorenal Syndrome Carries the Highest Risk of In-Hospital Mortality Among Hospitalized Patients With Primary Biliary Cholangitis

Monday, October 28

10:30 AM - 4:15 PM

Location: Exhibit Halls 3 and 4 (Street Level)

Presenting Author(s)

Artin Galoosian, MD, MA

Artin Galoosian, MD, MA¹, Grishma Hirode, MAS², Robert Wong, MD, MS, FACG³

¹California Pacific Medical Center, San Francisco, CA; ²Alameda Health System, Oakland, CA; ³Alameda Health System - Highland Hospital, Oakland, CA

Introduction: Primary biliary cholangitis (PBC) is an autoimmune and progressive cholestatic liver disease with significant morbidity and mortality. Hospitals with safety-net burden (SNB) provide an essential role to serving low-income and historically vulnerable populations. We aim to evaluate factors, including hospital SNB, associated with in-hospital mortality among hospitalizations with PBC.

Methods: Using the 2012-2014 National Inpatient Sample, we evaluated US adults hospitalized with PBC (using ICD-9 codes). Hospital SNB was defined as the percentage of hospitalizations among PBC with Medicaid or uninsured payer status per hospital, and was categorized into two groups: no SNB vs. any SNB. Between-group comparisons used chi-squared testing. Survey-weighted, adjusted multivariate logistic regression analysis was used to evaluate factors associated with in-hospital mortality.

Results: Among 7,364 hospitalizations with PBC (mean age 64.0+14.3y, 16.1% men, 70.3% non-Hispanic White), 65.3% were in no SNB and 34.7% were in low-high SNB hospitals. Crude in-hospital mortality was 4.15%, with no significant differences by hospital SNB. On adjusted regression, among the cirrhosis-related complications analyzed, the presence of ascites (OR 1.85, 95% CI 1.36-2.52, p< 0.001), hepatic encephalopathy (OR 2.32, 95% CI 1.75-3.08, p< 0.001) and hepatorenal syndrome (OR 7.58, 95% CI 5.12-11.2, p< 0.001) resulted in higher odds of in-hospital mortality compared to those without the respective complication present. Additionally, hospitalizations at urban teaching hospitals also had a higher odds of in-hospital mortality compared to rural hospitals (OR: 2.04, 95% CI: 1.20-3.46, p=0.01).

Discussion: Hospitalizations with PBC with concomitant cirrhosis-related complications had significantly higher odds of in-hospital mortality. Specifically, PBC hospitalizations with hepatorenal syndrome were 7.6 times more likely to die during hospitalization. Urban teaching hospitals also had higher in-hospital mortality compared to rural hospitals.

Among PBC-related hospitalizations, cirrhosis-related complications significantly increased in-hospital mortality. More specifically, hepatorenal syndrome was associated with the largest increase in in-hospital mortality.

Disclosures:

Artin Galoosian indicated no relevant financial relationships.

Grishma Hirode indicated no relevant financial relationships.

Robert Wong: Abbvie – Grant/Research Support. Gilead Sciences – Advisory Committee/Board Member, Consultant, Grant/Research Support, Speaker's Bureau. Salix – Speaker's Bureau.

Citation: Artin Galoosian, MD, MA; Grishma Hirode, MAS; Robert Wong, MD, MS, FACG. P0937 - HEPATORENAL SYNDROME CARRIES THE HIGHEST RISK OF IN-HOSPITAL MORTALITY AMONG HOSPITALIZED PATIENTS WITH PRIMARY BILIARY CHOLANGITIS. Program No. P0937. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.