Mohammad Maysara Asfari, MD1, Muhammad Talal Sarmini, MD2, Katherine Kendrick, MD3, Subbaramiah Sridhar, MD4, Humberto Sifuentes, MD5
1Augusta University, Augusta, GA; 2Cleveland Clinic Foundation, Cleveland, OH; 3Medical College of Georgia / Mercer University, Macon, GA; 4Georgia Medical College / Augusta University, Augusta, GA; 5Medical College of Georgia at Augusta University, Augusta, GA
Introduction: Inflammatory bowel disease (IBD) is a complex condition precipitated by genetic susceptibility and disturbed microbiome. The role of dairy foods in IBD has been controversial. Therefore, we aimed to investigate the association between lactose intolerance (LI) and IBD.
Methods: Data on hospital admissions of all IBD adult patients were extracted from the National Inpatient Sample (NIS) database between 2004 and 2014. Comorbidities and outcomes of interest were defined by querying all diagnostic and procedural fields for the corresponding ICD-9 codes. Patients who were diagnosed with IBD were defined (study group). The control group were the patients who did not have a diagnosis of IBD. LI diagnosis was identified in both study and control groups using the ICD-9 codes. Univariable and multivariate logistic regression was performed to study the association between IBD and LI.
Results: The total population was comprised of 71,342,237 patients, of which 598,129 (0.83%) were diagnosed with IBD. IBD patients were younger (52 vs 57) with fewer female (57.5% vs 60.1%) and African American patients (10% vs 14.3%) (P < 0.0001 for all).
In addition, the IBD patients had more tobacco use (14% vs 12%). After adjusting for the potential cofounding factors including age, race, gender, obesity and tobacco use, the IBD group had a statistically significant higher rate of LI (Odds Ratio [OR], 2.71, 95% confidence interval [CI], 2,55-2.88, P < 0.0001) compared to non-IBD group. The findings were similar on further stratification of IBD into Crohn’s disease compared to the control group (OR: 2.7, 95% CI: 2.50 – 2.92, P< 0.0001] and ulcerative colitis compared to the control group (OR: 2.71, 95% CI: 2.46 – 2.98, P< 0.0001]
Discussion: IBD patients have a 2.7 times higher risk of suffering from lactose intolerance. Screening for lactose intolerance in this population warranted to avoid confusing symptomatology with inflammatory bowel disease activity.
Citation: Mohammad Maysara Asfari, MD; Muhammad Talal Sarmini, MD; Katherine Kendrick, MD; Subbaramiah Sridhar, MD; Humberto Sifuentes, MD. P1434 - THE ASSOCIATION BETWEEN INFLAMMATORY BOWEL DISEASE AND LACTOSE INTOLERANCE. Program No. P1434. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.