Anas Raed, MD1, Jigar Bhagatwala, MBBS1, Muhammed Sherid, MD1, Humberto Sifuentes, MD2, Subbaramiah Sridhar, MD3, Amol Sharma, MBBS1
1Augusta University, Augusta, GA; 2Medical College of Georgia at Augusta University, Augusta, GA; 3Georgia Medical College / Augusta University, Augusta, GA
Introduction: Gallbladder cancer (GBC) is the most common malignancy of the biliary tract. The regional and interstate variations in the US are unknown but are of high importance for epidemiology and preventive strategies. We investigated the regional and state-specific incidence and annual percent change (APC) of various histologic types of in the US over last 15 years.
Methods: Data was extracted from National Program of Cancer Registries (NPCR) for the period 2001-2015 and Surveillance, Epidemiology and End Results (SEER) for the period 2000-2015. Age-adjusted incidence and APC were calculated in a stepwise manner to examine the trends among each of four US regions, followed by 13 individual SEER-reported states. SEER Stat software was used to analysis.
Results: There were 54,224 GBC cases from 2001 to 2015. The incidence of GBC remained unchanged in four regions of the US between 2001-2015. However, a significant increase in the incidence rate of other-type of GBC histology was noted compared to the rest of the histologies with APC of 1.9% in the South (CI: 1.1, 2.8%). A rising but non-significant increase in APC of GBC was noted in the West, Northeast, Midwest with APC of 1.1% (CI: 0.0, 2.2%), 0.6% (CI: -0.3, 1.4%), 0.2% (-0.8, 1.3%), respectively (table 1). Corresponding to NPCR data, all 13 SEER-reported states showed mixed pattern of increase and decrease in the APC of GBC incidence rate. When we noticed an upward trend of GBC incidence rate, it was mainly due to other histology such as California and New Jersey with APC 2.2% (CI: 1.1, 3.4%), 1.7% (CI: 0.0, 3.4%), respectively (table 2). The only exception was Washington where the trend was mainly due to adenocarcinoma 2.3 (0.1, 4.6).
Discussion: The GBC incidence appears to be disproportionately higher in some states, predominantly the “other” histological type. Further public health initiatives need to investigate any potential causes for the regional disparities of increasing EAC incidence.
Citation: Anas Raed, MD; Jigar Bhagatwala, MBBS; Muhammed Sherid, MD; Humberto Sifuentes, MD; Subbaramiah Sridhar, MD; Amol Sharma, MBBS. P1529 - REGIONAL VARIATIONS AND TRENDS IN THE GALLBLADDER CANCER IN THE USA. Program No. P1529. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.